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A fundamental question in neuroscience is how we perceive and respond to our environment. Our laboratory uses mouse molecular genetics, circuit mapping, and electrophysiological analyses to gain understanding of the development, organization, and function of neural circuits that underlie the sense of touch. Mouse molecular genetic approaches are used to identify, visualize, and functionally manipulate each of the physiologically defined classes of low-threshold mechanosensory neurons (LTMRs), the primary cutaneous sensory neurons that mediate the sense of touch. We have also gained genetic access to neurons that receive and process LTMR inputs in the spinal cord and propagate this information to the brain. Our current goals are to discover: 1) unique functions and properties of LTMR subtypes; 2) the organization and logic of synaptic connections between LTMR subtypes, spinal cord dorsal horn interneurons and projection neurons, and dorsal column nuclei neurons; 3) ascending pathways that underlie the perception of touch, 4) cellular and circuit level alterations that underlie touch sensitivity deficits in autism spectrum disorders and neuropathic pain, and; 5) mechanisms by which primary somatosensory neurons and touch circuit organization are established during development.
Research Interests
Papers共 209 篇Author StatisticsCo-AuthorSimilar Experts
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Lijun Qi, Michael Iskols, Rachel S Greenberg, Jia Yin Xiao,Annie Handler,Stephen D Liberles,David D Ginty
Natureno. 8018 (2024): 926-934
Nature Neuroscienceno. 3 (2024): 484-496
Neurologyno. 17_supplement_1 (2024)
Dawei Zhang,Josef Turecek,Seungwon Choi, Michelle Delisle, Caroline L Pamplona,Shan Meltzer,David D Ginty
bioRxiv : the preprint server for biology (2024)
Lijun Qi,Michael Iskols, David Shi, Pranav Reddy,Christopher Walker, Karina Lezgiyeva,Tiphaine Voisin,Mathias Pawlak,Vijay K. Kuchroo,Isaac M. Chiu,David D. Ginty, Nikhil Sharma
CELLno. 6 (2024): 1508-1526.e16
Harris S. Kaplan, Brandon L. Logeman,Kai Zhang,Celine Santiago, Noor Sohail, Serhiy Naumenko, Shannan J. Ho Sui,David D. Ginty,Bing Ren,Catherine Dulac
bioRxiv the preprint server for biology (2024)
Erica L Huey,Josef Turecek,Michelle M Delisle,Ofer Mazor,Gabriel E Romero, Malvika Dua, Zoe K Sarafis, Alexis Hobble,Kevin T Booth,Lisa V Goodrich,David P Corey,David D Ginty
bioRxiv : the preprint server for biology (2024)
Lijun Qi,Michael Iskols, David Shi, Pranav Reddy,Christopher Walker, Karina Lezgiyeva,Tiphaine Voisin,Mathias Pawlak,Vijay K. Kuchroo,Isaac Chiu,David D. Ginty, Nikhil Sharma
bioRxiv the preprint server for biology (2023)
bioRxiv (Cold Spring Harbor Laboratory) (2023)
Ding Liu,Mostafizur Rahman, Autumn Johnson,Iku Tsutsui-Kimura, Nicolai Pena, Mustafa Talay, Brandon L Logeman, Samantha Finkbeiner,Seungwon Choi, Athena Capo-Battaglia,Ishmail Abdus-Saboor,David D Ginty,
bioRxiv : the preprint server for biology (2023)
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