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My laboratory's research is centered on achieving a better understanding of and improving the management of pain. This work can be roughly divided into two distinct parts: pain physiology and diagnosis and pain therapy. In terms of pain diagnosis, my laboratory is focused on identifying biomolecular and physiological markers that are indicative of different pain pathologies and can be directive in choosing therapies for that pain state. Thus, we are examining changes in pain nerve (nociceptor) gene expression in skin and nerve tissue. For example, we have recently investigated changes in expression of voltage gated sodium channels under inflammatory and post-incisional conditions. We have also studied the release of neuropeptide, cytokine, and trophic biomarkers into skin and into the spinal epidural space during different pain and inflammatory states in rodents and humans and the effects of treatments on this release. This biomarker methodology is very useful in the process of analgesic and anti-inflammatory therapy development.
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Frederick Godley III,John Meitzen,Hadas Nahman-Averbuch, Mary Angela O'Neal,David Yeomans,Nanette Santoro, Nina Riggins,Lars Edvinsson
JOURNAL OF PERSONALIZED MEDICINEno. 2 (2024): 184
John V. Mulcahy,Jacob T. Beckley, Sheri D. Klas, Debra A. Odink,Anton Delwig,Hassan Pajouhesh,Dennis Monteleone,Xiang Zhou,Justin Du Bois,David C. Yeomans, George Luu, John C. Hunter
British Journal of Pharmacology (2024)
John V Mulcahy,Jacob T Beckley, Sheri D Klas, Debra A Odink,Anton Delwig,Hassan Pajouhesh,Dennis Monteleone,Xiang Zhou,Justin Du Bois,David C Yeomans, George Luu, John C Hunter
British journal of pharmacology (2024)
Regional anesthesia and pain medicineno. 9 (2023): 462-470
The journal of painno. 10 (2023): 1859-1874
Authorea (Authorea) (2022)
HEADACHEno. 7 (2021): 1051-1059
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