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个人简介
Dr. Borchelt’s research is focused on defining the basic molecular events that underlie human neurodegenerative diseases, and using this information to develop new therapeutic strategies. To accomplish these goals, his lab uses a variety of model systems to understand how mutations in specific genes cause diseases such as amyotrophic lateral sclerosis (ALS) and Alzheimer’s disease. As they have begun to decipher the mechanisms of these diseases, his lab has found common features that implicate common pathways. One of the common features of these disorders is the presence of pathological structures in brain or spinal cord that are composed of misfolded proteins. Recent studies have revealed that the misfolded pathologic proteins in ALS and Alzheimer’s disease can exhibit prion-like properties to mediate the spread of pathology throughout the brain or spinal cord. His lab is currently focused on understanding the mechanisms by which pathology seems to spread in the nervous system and identify therapies to slow this spread.
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论文共 353 篇作者统计合作学者相似作者
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bioRxiv : the preprint server for biology (2024)
Molecular Neurodegenerationno. 1 (2024): 1-2
Guilian Xu, Patricia Sacilotto, Carmelina Gorski, Parul Bali,Susan Fromholt,Quan Vo,Karen N McFarland, Qing Lu,David R Borchelt, Paramita Chakrabaty
crossref(2024)
Acta neuropathologica communicationsno. 1 (2023): 119-22
Yona Levites,Eric B Dammer,Yong Ran,Wangchen Tsering,Duc Duong,Measho Abreha, Joshna Gadhavi, Kiara Lolo,Jorge Trejo-Lopez,Jennifer L Phillips, Andrea Iturbe, Aya Erqiuzi,
bioRxiv : the preprint server for biology (2023)
Virusesno. 1819 (2023): 1819-1819
Acta neuropathologica communicationsno. 1 (2023): 1-13
Acta neuropathologica communicationsno. 1 (2023): 99-19
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