When some cells divide in an abnormal manner, the body activates anti-cancer mechanisms in order to protect itself. It, thus, orders the senescence of abnormal cells, in other words it provokes a “biological ageing” leading to the inhibition of cellular proliferation. However, some malignant cells manage to “evade” such as a defence mechanism. David Bernard conducts research at the CRCL, under the supervision of Alain Puisieux, focusing on the determination of the genetic modifications associated with these escape mechanisms.