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个人简介
Dr. Kass' research aims to expand our understanding of cardiac disease in its many manifestations, to identify novel mechanisms and avenues for treatment, and ultimately translate them to therapies in the clinic. Under his Directorship, the ICS broadly works to understand causes of cardiovascular disease using molecular and cellular biology, organ and whole animal models, regenerative medicine approaches, and bio-engineering to develop new methods for diagnosis and treatment. In his lab, Dr. Kass and colleagues have discovered a number of new methods to treat heart failure with depressed heart function, including a form of nitric oxide called nitroxyl, an inhibitor of phosphodiesterase type 1 and type 9, a mutant form of a protein involved with protein quality control called Chip, and using a novel pacemaker strategy termed PITA. He pioneered research into how a major enzyme known as Protein Kinase G functions in the heart muscle, and how its activation can benefit heart disease. This has resulted in new discoveries with applications to heart failure, obesity, muscular dystrophy, cardiac hypertrophy and fibrosis, and even immune-cancer therapy.
研究兴趣
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Virginia S. Hahn,Hildur Knutsdottir,Tess E. Peterson, Daniel Kikuchi, Soumya Vungarala,David A. Kass,Kavita Sharma
Cardiovascular research (2024)
PNAS NEXUSno. 2 (2024): pgae039-pgae039
Mariam Meddeb,Navid Koleini,Seungho Jun,Mohammad Keykhaei, Farnaz Farshidfar,Liang Zhao, Abigail Mulligan, Seoyoung Kwon,Brian Lin,Gizem Keceli,Kavita Sharma,Mark J. Ranek,
CIRCULATION (2023)
JACC: Heart Failureno. 2 (2023): 240-242
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