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Investigations into the formation and loss of the blood-brain and blood-retinal barrier in normal vascular biology, diabetes and cancer
Our long-term goal is to contribute to the development of novel treatments to prevent or reverse the debilitating loss of vision from diabetes and stroke.
The tight junction complex contributes an essential role in multi-cellular organisms by helping to create defined environments between tissues. Tight junctions create a tight seal between cells controlling the flux of fluids, proteins and even ions across tissue barriers. These barriers provide an essential function in a variety of tissues including the intestine, lung and kidneys. Our laboratory is specifically interested in the tight junction complex in specialized regions of the vasculature that help to create the blood-brain and blood-retinal barrier. The tight junctions that connect the endothelial cells in the brain and retina are needed for normal neural function and contribute to the neurovascular unit. This vascular barrier may be compromised in a variety of disease states.
Our long-term goal is to contribute to the development of novel treatments to prevent or reverse the debilitating loss of vision from diabetes and stroke.
The tight junction complex contributes an essential role in multi-cellular organisms by helping to create defined environments between tissues. Tight junctions create a tight seal between cells controlling the flux of fluids, proteins and even ions across tissue barriers. These barriers provide an essential function in a variety of tissues including the intestine, lung and kidneys. Our laboratory is specifically interested in the tight junction complex in specialized regions of the vasculature that help to create the blood-brain and blood-retinal barrier. The tight junctions that connect the endothelial cells in the brain and retina are needed for normal neural function and contribute to the neurovascular unit. This vascular barrier may be compromised in a variety of disease states.
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Tien-En Tan,Lee M. Jampol,Frederick L. Ferris,Ramin Tadayoni,Srinivas R. Sadda,Victor Chong,Amitha Domalpally,Barbara L. Blodi,Elia J. Duh, Christine A. Curcio,David A. Antonetti, Sanjoy Dutta,
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Cellsno. 19 (2023): 2402-2402
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