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个人简介
The research interests of Darren J. Baker, M.S., Ph.D., are focused on the involvement of senescent cells in the processes of aging and cancer.
Cellular senescence, a state of irreversible cell cycle arrest that limits the ability of cells to divide, is a potent anti-tumor mechanism that is also a common feature of aged tissue. Instead of simply being resident cells within a tissue, senescent cells promote various age-related phenotypes due to components that they secrete. Studying the role of cellular senescence in vivo, however, has been difficult due to the lack of reliable markers and the inability to selectively manipulate these cells in animals.
Dr. Baker's research team has developed a transgenic mouse model, termed INK-ATTAC, in which p16-expressing senescent cells can be selectively eliminated in an inducible fashion. By using the INK-ATTAC model in combination with an accelerated aging model, Dr. Baker has demonstrated the ability to significantly delay age-related pathologies and phenotypes, including cataract formation, by removing senescent cells.
Cellular senescence, a state of irreversible cell cycle arrest that limits the ability of cells to divide, is a potent anti-tumor mechanism that is also a common feature of aged tissue. Instead of simply being resident cells within a tissue, senescent cells promote various age-related phenotypes due to components that they secrete. Studying the role of cellular senescence in vivo, however, has been difficult due to the lack of reliable markers and the inability to selectively manipulate these cells in animals.
Dr. Baker's research team has developed a transgenic mouse model, termed INK-ATTAC, in which p16-expressing senescent cells can be selectively eliminated in an inducible fashion. By using the INK-ATTAC model in combination with an accelerated aging model, Dr. Baker has demonstrated the ability to significantly delay age-related pathologies and phenotypes, including cataract formation, by removing senescent cells.
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论文共 212 篇作者统计合作学者相似作者
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Vidyani Suryadevara,Adam D Hudgins, Adarsh Rajesh,Alberto Pappalardo,Alla Karpova,Amit K Dey,Ann Hertzel,Anthony Agudelo,Azucena Rocha, Bikem Soygur,Birgit Schilling,Chase M Carver,
Nature reviews. Molecular cell biologypp.1-23, (2024)
Camille Laliberte, Bianca Bosse,Veronique Bourdeau,Luis I. Prieto, Geneve Perron-Deshaies,Nhung Vuong-Robillard,Sebastian Igelmann,Lisbeth Carolina Aguilar,Marlene Oeffinger,Darren J. Baker,Luc DesGroseillers,Gerardo Ferbeyre
BIOMEDICINESno. 5 (2024): 1089
JOURNAL OF ALZHEIMERS DISEASEno. 3 (2024): 925-940
Journal of Alzheimer's disease : JADno. 4 (2024): 1751-1763
Psychosomatic medicineno. 5 (2023): 366-378
NPJ precision oncologyno. 1 (2023): 126-126
FEBS JOURNALno. 5 (2023): 1156-1160
Nature Communicationsno. 1 (2023): 1-17
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