Research Interests: Dr. Brann’s research has contributed significantly to enhancing understanding of 17b-estradiol (estrogen) signaling mechanisms and actions in the brain, including its anti-oxidative stress, anti-inflammatory, and neuroprotective actions in the brain. His recent work has focused upon elucidating the role of “brain-derived” estrogen, from both neurons and astrocytes, in neural plasticity, neuroinflammation, astrocyte biology, and neuronal survival, as well as in control of cognitive function. In addition, his recent work has also focused on elucidating the role of astrocytes and the ROS-generating enzyme, NADPH oxidase in oxidative stress, stroke and traumatic brain injury.