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The Irvine laboratory works at the interface of materials science and immunology. Synthetic materials can be applied in two major ways to 'immunobioengineering': (1) Synthetic materials can modulate the function of immune cells by mimicking signals derived from the immune system or foreign pathogens, both as a probe for cell function and as a tool for immunotherapy— both in vitro and in vivo; (2) Synthetic materials can be used to create in vitro and in vivo models of the microenvironment present in lymphoid and non-lymphoid tissues, to better understand immunobiology in health and disease. To meet these goals, engineering must be married to an in-depth appreciation for the biology of these problems. Their laboratory is thus deeply interdisciplinary in every project. Key to their approach is a balanced emphasis on both the engineering and immunological aspects of the problems the Irvine group has chosen to address: In each of these projects, state of the art chemistry, polymer science, physics and immunology are combined to address critical biological questions and medical challenges.
The Irvine laboratory works at the interface of materials science and immunology. Synthetic materials can be applied in two major ways to 'immunobioengineering': (1) Synthetic materials can modulate the function of immune cells by mimicking signals derived from the immune system or foreign pathogens, both as a probe for cell function and as a tool for immunotherapy— both in vitro and in vivo; (2) Synthetic materials can be used to create in vitro and in vivo models of the microenvironment present in lymphoid and non-lymphoid tissues, to better understand immunobiology in health and disease. To meet these goals, engineering must be married to an in-depth appreciation for the biology of these problems. Their laboratory is thus deeply interdisciplinary in every project. Key to their approach is a balanced emphasis on both the engineering and immunological aspects of the problems the Irvine group has chosen to address: In each of these projects, state of the art chemistry, polymer science, physics and immunology are combined to address critical biological questions and medical challenges.
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论文共 492 篇作者统计合作学者相似作者
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Leyuan Ma, Ranjani Ramasubramanian,Naveen K Mehta,Benjamin Cossette,Duncan M Morgan, Ina Sukaj,Elisa Bergaggio,Stephan Kadauke,Regina M Myers,Luca Paruzzo,Guido Ghilardi, Tomasz M Grzywa,
bioRxiv : the preprint server for biology (2024)
bioRxiv : the preprint server for biology (2024)
JOURNAL OF IMMUNOLOGYno. 2 (2024): 171-178
Luciano Santollani,Yiming J Zhang,Laura Maiorino,Joseph R Palmeri,Jordan A Stinson,Lauren R Duhamel,Kashif Qureshi, Jack R Suggs, Owen T Porth,William Pinney, Riyam Al Msari,K Dane Wittrup,
bioRxiv : the preprint server for biology (2024)
Yonger Xue,Yuebao Zhang,Yichen Zhong,Shi Du,Xucheng Hou,Wenqing Li, Haoyuan Li, Siyu Wang,Chang Wang,Jingyue Yan,Diana D. Kang, Binbin Deng,
Nature Communicationsno. 1 (2024): 1-13
bioRxiv : the preprint server for biology (2023)
Carley A. Owens,Zachariah Tritz,Katayoun Ayasoufi, Delaney Wolf,Ian F. Parney, Michael A. Hanson,Fang Jin,Aaron J. Johnson,Jian Campian,Cori E. Fain,Benjamin Himes,Courtney S. Malo,
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Nature Reviews Bioengineeringno. 2 (2023): 107-124
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