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The Irvine laboratory works at the interface of materials science and immunology. Synthetic materials can be applied in two major ways to 'immunobioengineering': (1) Synthetic materials can modulate the function of immune cells by mimicking signals derived from the immune system or foreign pathogens, both as a probe for cell function and as a tool for immunotherapy— both in vitro and in vivo; (2) Synthetic materials can be used to create in vitro and in vivo models of the microenvironment present in lymphoid and non-lymphoid tissues, to better understand immunobiology in health and disease. To meet these goals, engineering must be married to an in-depth appreciation for the biology of these problems. Their laboratory is thus deeply interdisciplinary in every project. Key to their approach is a balanced emphasis on both the engineering and immunological aspects of the problems the Irvine group has chosen to address: In each of these projects, state of the art chemistry, polymer science, physics and immunology are combined to address critical biological questions and medical challenges.
The Irvine laboratory works at the interface of materials science and immunology. Synthetic materials can be applied in two major ways to 'immunobioengineering': (1) Synthetic materials can modulate the function of immune cells by mimicking signals derived from the immune system or foreign pathogens, both as a probe for cell function and as a tool for immunotherapy— both in vitro and in vivo; (2) Synthetic materials can be used to create in vitro and in vivo models of the microenvironment present in lymphoid and non-lymphoid tissues, to better understand immunobiology in health and disease. To meet these goals, engineering must be married to an in-depth appreciation for the biology of these problems. Their laboratory is thus deeply interdisciplinary in every project. Key to their approach is a balanced emphasis on both the engineering and immunological aspects of the problems the Irvine group has chosen to address: In each of these projects, state of the art chemistry, polymer science, physics and immunology are combined to address critical biological questions and medical challenges.
Research Interests
Papers共 505 篇Author StatisticsCo-AuthorSimilar Experts
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Ozgun Kocabiyik, Parastoo Amlashi, A Lina Vo,Heikyung Suh,Sergio A Rodriguez-Aponte,Neil C Dalvie, J Christopher Love,Raiees Andrabi,Darrell J Irvine
Science advancesno. 22 (2024): eadn7786-eadn7786
Leyuan Ma, Ranjani Ramasubramanian,Naveen Mehta,Benjamin Cossette,Duncan Morgan, Ina Sukaj,Elisa Bergaggio,Stephan Kadauke,Regina Myers,Luca Paruzzo,Guido Ghilardi, Tomasz Grzywa,
bioRxiv : the preprint server for biology (2024)
Elisa Bergaggio, Wei-Tien Tai,Andrea Aroldi,Carmen Mecca,Elisa Landoni,Manuel Nüesch,Ines Mota, Jasna Metovic,Luca Molinaro, Leyuan Ma,Diego Alvarado,Chiara Ambrogio,
Cancer Researchno. 6_Supplement (2024): 50-50
bioRxiv the preprint server for biology (2024)
Journal of immunology (Baltimore, Md. : 1950)no. 2 (2024): 171-178
Kristina R Edwards, Karina Schmidt,Leah J Homad, Gargi M Kher, Guoyue Xu,Kristen A Rodrigues,Elana Ben-Akiva, Joe Abbott,Martin Prlic, Evan W Newell,Stephen C De Rosa,Darrell J Irvine,
Cell reports. Medicineno. 6 (2024): 101587-101587
Kristina R. Edwards, Karina Schmidt,Leah J. Homad, Gargi M. Kher, Guoyue Xu,Kristen A. Rodrigues,Elana Ben-Akiva, Joe Abbott,Martin Prlic, Evan W. Newell,Stephen C. De Rosa,Darrell J. Irvine,
Cell Reports Medicine (2024)
Luciano Santollani,Yiming J Zhang,Laura Maiorino,Joseph R Palmeri,Jordan A Stinson,Lauren R Duhamel,Kashif Qureshi, Jack R Suggs, Owen T Porth,William Pinney, Riyam Al Msari,K Dane Wittrup,
bioRxiv : the preprint server for biology (2024)
Nature Communicationsno. 1 (2024): 1-13
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