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Altieri is interested in how mechanisms of cellular adaptation or “plasticity” are universally exploited in cancer for disease maintenance and progression. Multiple cellular pathways of response to stress, metabolic rewiring, and control of cell death are invariably subverted in human tumors, and often confer more aggressive disease traits including the ability to disseminate to distant organs, or metastasis. A detailed, molecular, cellular, and genetic understanding of tumor plasticity could uncover new therapeutic targets and identify novel approaches to interfere with metastatic competence, which remains the primary cause of death for cancer patients.
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Cancer Researchno. 6_Supplement (2024): 4380-4380
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Tao Wang, Jiayi Huang,Mai Vue,Michael R. Alavian,Hira Lal Goel,Dario C. Altieri,Lucia R. Languino,Thomas J. FitzGerald
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ISME COMMUNICATIONSno. 1 (2023): 128-128
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