基本信息
views: 41
![](https://originalfileserver.aminer.cn/sys/aminer/icon/show-trajectory.png)
Bio
My research focuses on the mechanisms by which biological systems harness the generation of reactive species to modulate cell signaling pathways and maintain physiological homeostasis. My group is particularly interested in elucidating the mechanisms that result in the formation of electrophilic species in vivo. Electrophiles can regulate enzymatic and transcription factor function via covalent modification of reactive cysteine residues. In this regard, our overarching hypothesis is that the endogenous generation of electrophilic species in vivo is a conserved mechanism for maintaining physiological homeostasis and regulating inflammatory responses. Enabled by collaboration with basic and clinical scientists, we have studied the effects of endogenous electrophiles in pathological conditions such as sickle cell disease, acute and chronic renal injury, as well as cardiac arrest, both at the pre-clinical and clinical level. Finally, I maintain a keen interest in general redox biochemistry as well as in nitric oxide and metallo-protein biology.
Research Interests
Papers共 79 篇Author StatisticsCo-AuthorSimilar Experts
By YearBy Citation主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Redox Biochemistry and Chemistry (2024): 100026
Redox biology (2023): 102636-102636
Redox biology (2023): 102866-102866
BLOOD (2023): 3857
Free Radical Biology and Medicine (2023): S86-S86
Redox Chemistry and Biology of Thiolspp.177-196, (2022)
Load More
Author Statistics
Co-Author
Co-Institution
D-Core
- 合作者
- 学生
- 导师
Data Disclaimer
The page data are from open Internet sources, cooperative publishers and automatic analysis results through AI technology. We do not make any commitments and guarantees for the validity, accuracy, correctness, reliability, completeness and timeliness of the page data. If you have any questions, please contact us by email: report@aminer.cn