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Most front line anticancer agents are DNA-targeted small molecules which are highly potent but less selective. Cancer-specific molecular targets have become a frontier for new anticancer drug development. My research program focuses on structures and functions of cancer-specific DNA molecular targets and structure-based rational design of new anticancer drugs. Our goal is to combine the potential of DNA-interactive anticancer compounds with the selectivity properties of molecular-targeted approaches. We work on a number of DNA molecular targets for cancer therapeutics, including DNA secondary structures such as G-quadruplexes, their biological functions and molecular interactions with small molecules and proteins, as well as targeting DNA binding of transcription factors by DNA bis-intercalating drugs. Research in my laboratory involves a variety of biophysical, biochemical, molecular and cellular biology methods, in particular high-field NMR spectroscopy. NMR represents a major method for structural study of biologically relevant DNA secondary structures.
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Papers共 158 篇Author StatisticsCo-AuthorSimilar Experts
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METHODS (2024): 35-41
Muhammad Safdar,Hang Lin, Sarah Dagher,Jonathan Dickerhoff, Mitchell Ayers, Luis Solorio,Danzhou Yang,Michael Wendt, Saeed Akhand
Cancer Researchno. 9_Supplement (2024): PO2-18
Journal of the American Society for Mass Spectrometryno. 4 (2024): 756-766
Engineering (2024)
Yichen Han, Adam Buric, Venkat Chintareddy, Mercedes DeMoss,Luying Chen,Jonathan Dickerhoff, Robyn De Dios,Pooran Chand, Randall Riggs,Danzhou Yang,Mark Cushman
Cancer Researchno. 6_Supplement (2024): 5775-5775
CANCER RESEARCHno. 7 (2023)
Handbook of Chemical Biology of Nucleic Acidspp.1-30, (2023)
CANCER RESEARCHno. 7 (2023)
CANCER RESEARCHno. 7 (2023)
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