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职业迁徙
个人简介
Understanding the emergence and spread of antimicrobial resistance is one of the grand challenges for global human health, but it is also a fascinating biological problem, concerning the evolution of populations experiencing complex environmental conditions.
My research combines experimental, mathematical, and bioinformatic approaches to predict how and when bacteria will evolve antibiotic resistance under biologically-realistic growth conditions. The aim of this research is to develop a rational framework for designing combination therapies to suppress resistance evolution and regain usefulness of antibiotics where resistance has become wide-spread. This work is crucial for establishing combination therapies as a viable solution to the antibiotic resistance crisis. The project is funded through a UKRI Rutherford Fellowship, involving collaborations with Tobias Galla, Chris Knight, and Simon Lovell.
I am also involved in a multi-disciplinary BBSRC project to study the adaptive landscapes of antibiotic resistance evolution. This project combines wet-lab experimental evolution with mathematical models and advanced computer simulations to predict how population size and mutational target size interact to shape resistance evolution. I am also collaborating with Rok Krašovec on the effects of mutation rate plasticity on the evolutionary genomics of E. coli.
My research combines experimental, mathematical, and bioinformatic approaches to predict how and when bacteria will evolve antibiotic resistance under biologically-realistic growth conditions. The aim of this research is to develop a rational framework for designing combination therapies to suppress resistance evolution and regain usefulness of antibiotics where resistance has become wide-spread. This work is crucial for establishing combination therapies as a viable solution to the antibiotic resistance crisis. The project is funded through a UKRI Rutherford Fellowship, involving collaborations with Tobias Galla, Chris Knight, and Simon Lovell.
I am also involved in a multi-disciplinary BBSRC project to study the adaptive landscapes of antibiotic resistance evolution. This project combines wet-lab experimental evolution with mathematical models and advanced computer simulations to predict how population size and mutational target size interact to shape resistance evolution. I am also collaborating with Rok Krašovec on the effects of mutation rate plasticity on the evolutionary genomics of E. coli.
研究兴趣
论文共 33 篇作者统计合作学者相似作者
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Danna R Gifford,Anish Bhattacharyya, Alexandra Geim, Eleanor Marshall,Rok Krašovec,Christopher G Knight
Microbiology (Reading, England)no. 4 (2024)
Selina Lindon, Sarah Shah,Danna R. Gifford, Maria A. Gomis Font,Divjot Kaur,Antonio Oliver,R. Craig MacLean,Rachel M. Wheatley
biorxiv(2023)
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PLoS geneticsno. 6 (2023): e1010791-e1010791
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Evolutionary Applicationsno. 10 (2023): 1663-1670
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MICROBIOLOGY-SGMno. 11 (2023)
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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Danna Gifford, Katherine Atkins
semanticscholar(2021)
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