基本信息
浏览量:4
职业迁徙
个人简介
Highly organized self-assembling proteins abound in the living world, and the resulting assemblies govern critical processes at all levels of life, from the formation of virus capsids to the transport of oxygen in the blood. The Tullman-Ercek lab is interested in several questions related to self-assembling systems: 1) What fundamental principles govern the precise organization of proteins at the nanoscale? 2) How does organization of biochemical processes enhance their performance? 3) How can we manipulate these protein assemblies to gain new or enhanced functions in living systems? Answering these questions permits advances in a wide range of application spaces, including vaccine development, manufacturing of therapeutics, and sustainable chemical production. Our current model systems include protein containers such as the MS2 viral capsid and bacterial organelles called microcompartments, and membrane protein machines such as the type III secretion system and multidrug efflux pumps. In the process of trying to engineer these systems to gain or improve function, we often make surprising observations that lead to new, hypothesis-driven inquiries. Our current work focuses on engineering new vaccine scaffolds, cancer therapeutics, and microbial biochemical biosynthesis processes.
研究兴趣
论文共 25 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn