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In Renal Division of the Brigham and Women's Hospital, in 1993 we identified the first G protein-coupled receptor for an ion, calcium. The paper describing the cloning of the Calcium-Sensing Receptor, CaSR, from parathyroid glands is now a "citation classic" with >2,000 citations. While in Prof Hebert lab, I was awarded a Research Fellowship from the National Kidney Foundation to identify the renal CaSR. The parathyroid and kidney CaR are the target for a novel class of small molecule drugs, the calcimimetics, which were developed for the treatment of chronic kidney disease. In 2004, calcimimetics were the first G protein-coupled receptor allosteric modulators to enter the market and in 2014 calcimimetics were within the top 100 most sold drugs.
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IUPHAR/BPS guide to pharmacology CITEno. 1 (2023)
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Frontiers in Physiology (2023): 1225074
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Kasope L. Wolffs,Daniel A. Pass,Beth Mansfield,Richard T. Bruce, Petar A. Popov,Christopher J. Corrigan,Jeremy P. T. Ward,Paul J. Kemp, Benjamin Hope-Gill,Daniela Riccardi
IUPHAR/BPS Guide to Pharmacology CITEno. 3 (2021)
medRxiv (Cold Spring Harbor Laboratory) (2020)
semanticscholar(2020)
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