基本信息
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Bio
The overall objective of Dr. Daniel Gonzalez’s research program is to optimize pharmacotherapeutic efficacy and safety through the use of clinical and experimental data, and the application of mathematical modeling and simulation techniques, with an emphasis in pediatric populations. This is first accomplished by characterizing the differences in pharmacokinetic (PK) and pharmacodynamic (PD) relationships across human development, elucidating and quantifying influential factors of drug disposition, and the degree of interindividual variability surrounding them. Assessment of such changes are then related to deviations in drug effects and overall patient outcomes. With such characterizations established, optimal dosing regimens are derived, with a clinical impact in patient populations for which evidence-based dosing recommendations are frequently absent.
The Gonzalez Lab is currently focused on research in the following areas:
Characterizing drug pharmacokinetics/pharmacodynamics in the pediatric population
Studying the effect of obesity on pharmacokinetics and drug dosing in children and adolescents
Evaluating drug-drug interactions in the pediatric population
Use of real-world data to evaluate drug safety and efficacy
Drug dosing individualization
Research Interests
Papers共 290 篇Author StatisticsCo-AuthorSimilar Experts
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Stephen J Balevic,Daniel K Benjamin,William G Powderly,P Brian Smith,Daniel Gonzalez,Matthew W McCarthy, Linda K Shaw,Christopher J Lindsell, Sam Bozzette, Daphne Williams,Benjamin P Linas, John Blamoun,
JAMA network openno. 4 (2024): e247615-e247615
Sean McCann, Victoria E. Helfer,Stephen J. Balevic,Chi D. Hornik,Stuart L. Goldstein,Julie Autmizguine, Marisa Meyer,Amira Al-Uzri, Sarah G. Anderson,Elizabeth H. Payne, Sitora Turdalieva,Daniel Gonzalez
JOURNAL OF CLINICAL PHARMACOLOGY (2024)
Patricia D. Maglalang,Jaydeep Sinha,Kanecia Zimmerman, Sean McCann,Andrea Edginton,Christoph P. Hornik,Chi D. Hornik,William J. Muller,Amira Al-Uzri, Marisa Meyer,Jia-Yuh Chen,Ravinder Anand,
Clinical Pharmacokineticspp.1-15, (2024)
Elizabeth J Thompson, Angela Jeong, Victória E Helfer,Valentina Shakhnovich,Andrea Edginton, Stephen J Balevic,Laura P James,David N Collier,Ravinder Anand,Daniel Gonzalez, Best Pharmaceuticals for Children Act – Pediatric Trials Network Steering Committee
CPT: pharmacometrics & systems pharmacology (2024)
Journal of clinical pharmacologyno. 6 (2024): 728-736
CLINICAL PHARMACOLOGY & THERAPEUTICSno. 4 (2023): 762-767
International Journal of Molecular Sciencesno. 24 (2023): 17168
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