Daniel A Portnoy
Distinguished Professor
College of Letters & Science
Department of Molecular & Cell Biology, University of California, Berkeley;College of Letters & Science, Department of Plant & Microbial Biology, University of California, Berkeley;Division of Biochemistry, Biophysics, and Structural Biology, College of Letters & Science, University of California, Berkeley;Division of Immunology & Pathogenesis, College of Letters & Science, University of California, Berkeley
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Research
Intracellular pathogens are responsible for an enormous amount of worldwide morbidity and mortality and the development of vaccines and therapeutics to treat diseases caused by these pathogens continues to represent one of the biggest challenges facing the international biomedical community. By virtue of their intracellular niche, these pathogens avoid extracellular immune defense mechanisms, and consequently, vaccine strategies that target the production of antibodies have been largely ineffective. The Portnoy lab tackles a wide range of problems related to the pathogenesis and host response to intracellular pathogens with the goal of developing vaccines and therapeutics. Specifically, the lab works on Listeria monocytogenes, a facultative intracellular food-borne bacterial pathogen that is an outstanding model system with which to dissect basic aspects of host-pathogen interactions. Research includes many topics including basic microbiology the cell biology of infection, innate immune responses, acquired immunity, and vaccine development to both infectious diseases and cancer.
Intracellular pathogens are responsible for an enormous amount of worldwide morbidity and mortality and the development of vaccines and therapeutics to treat diseases caused by these pathogens continues to represent one of the biggest challenges facing the international biomedical community. By virtue of their intracellular niche, these pathogens avoid extracellular immune defense mechanisms, and consequently, vaccine strategies that target the production of antibodies have been largely ineffective. The Portnoy lab tackles a wide range of problems related to the pathogenesis and host response to intracellular pathogens with the goal of developing vaccines and therapeutics. Specifically, the lab works on Listeria monocytogenes, a facultative intracellular food-borne bacterial pathogen that is an outstanding model system with which to dissect basic aspects of host-pathogen interactions. Research includes many topics including basic microbiology the cell biology of infection, innate immune responses, acquired immunity, and vaccine development to both infectious diseases and cancer.
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论文共 241 篇作者统计合作学者相似作者
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Victoria Chevée,Karthik Hullahalli,Katherine G Dailey, Leslie Güereca, Chenyu Zhang,Matthew K Waldor,Daniel A Portnoy
Proceedings of the National Academy of Sciences of the United States of Americano. 17 (2024): e2320311121-e2320311121
Jesse Garcia Castillo, Sebastian Fernandez, Timothy Campbell, Jacob Williams, Diego Gonzalez-Ventura, Julia Ybarra, Nicole Flores Hernandez, Elina Wells,Daniel A. Portnoy,Michel DuPage
biorxiv(2024)
Infection and immunityno. 3 (2024): e0042223-e0042223
mBiono. 5 (2023)
Journal of Immunologyno. 1 (2023): 145.17-145.17
PLoS pathogensno. 6 (2023): e1011088-e1011088
crossref(2022)
Daisy X. Ji,Kristen C. Witt,Dmitri I. Kotov,Shally R. Margolis,Alexander Louie, Victoria Chevée,Katherine J. Chen,Moritz Gaidt, Harmandeep S. Dhaliwal,Angus Y. Lee,Stephen Nishimura,Dario S. Zamboni,
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