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My research focuses on bacteriophage-encoded enzymes, known as endolysins, that have the ability to rapidly bind to and degrade the bacterial cell wall. As such, they represent an alternative approach to conventional antibiotics. In 2001, while still a postdoctoral fellow at The Rockefeller University in Vince Fischetti's laboratory, I conducted the first study that demonstrated in vivo efficacy of an endolysin against a bacterial infection. The next several years represented a tremendous expansion in the discovery of new endolysins as well as studies aimed at evaluation of host-range, resistance, toxicity, and pharmacokinetics of these enzymes. Currently, at least three pharmaceutical companies are conducting human clinical trials with endolysins, with one in late-stage Phase III trials. In 2007, I moved to the University of Maryland where my laboratory began to focus on structure/function studies for several of the more active endolysins. Based on this collected knowledge, my group is now generating endolysins with more desirable attributes, such as higher activity, an expanded host range, or a more favorable thermostability profile. It is anticipated these bioengineering approaches will result in development of the next generation endolysins with enhanced properties.
Research Interests
Papers共 161 篇Author StatisticsCo-AuthorSimilar Experts
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Ecologyno. 6 (2024): e4314-e4314
Frontiers in immunology (2023): 1075774
FUNCTIONAL ECOLOGYno. 7 (2023): 1989-2001
Ryohei Urata,Hong Liu,Kevin Yasumura, Erji Mao,Jill Berger, Xiang Zhou,Cedric Lam,Roy Bannon, Darren Hutchinson,Daniel Nelson,Leon Poutievski,Arjun Singh,
2023 Optical Fiber Communications Conference and Exhibition (OFC)pp.1-3, (2023)
ACS infectious diseasesno. 5 (2023): 1092-1104
Hong Liu,Ryohei Urata,Kevin Yasumura, Xiang Zhou,Roy Bannon,Jill Berger, Pedram Dashti,Norm Jouppi,Cedric Lam,Sheng Li, Erji Mao,Daniel Nelson,
PROCEEDINGS OF THE 2023 ACM SIGCOMM 2023 CONFERENCE, SIGCOMM 2023pp.499-515, (2023)
Daniel Nelson, Scott W. Miller
HYDROBIOLOGIAno. 7 (2023): 1601-1617
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