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Research Summary/Interests
Biological and biochemical nature of immune self-tolerance
T cell immune tolerance
T cell clonal expansion
Breakdown of B cell tolerance during autoimmune disease development
Rheumatoid Arthritis
Systemic Lupus Erythematosus
Current Research Efforts:
Autoimmunity develops as the consequence of a loss of tolerance to self-antigens. Investigations carried out by Dr. Daniel Mueller are leading to a better understanding of the biological and biochemical nature of immune self-tolerance. Of particular interest are those factors that determine whether prolonged and continuous antigen stimulation of a T cell will lead to an increase in the clone size and the development of protective (or pathological) effector function, or alternatively lead to functional inactivation (anergy) and T regulatory cell (Treg) differentiation. To approach this problem, Mueller's research team is currently using an assortment of genomics and bioinformatics techniques (scRNA-Seq, ATAC-Seq) to characterize gene regulatory patterns in CD4 T cells that are associated with anergy induction and Foxp3+ Treg generation. Candidate gene regulators are being interrogated within neonatal mice--a time at which peripheral tolerance induction is essential for the avoidance of autoimmunity.
Biological and biochemical nature of immune self-tolerance
T cell immune tolerance
T cell clonal expansion
Breakdown of B cell tolerance during autoimmune disease development
Rheumatoid Arthritis
Systemic Lupus Erythematosus
Current Research Efforts:
Autoimmunity develops as the consequence of a loss of tolerance to self-antigens. Investigations carried out by Dr. Daniel Mueller are leading to a better understanding of the biological and biochemical nature of immune self-tolerance. Of particular interest are those factors that determine whether prolonged and continuous antigen stimulation of a T cell will lead to an increase in the clone size and the development of protective (or pathological) effector function, or alternatively lead to functional inactivation (anergy) and T regulatory cell (Treg) differentiation. To approach this problem, Mueller's research team is currently using an assortment of genomics and bioinformatics techniques (scRNA-Seq, ATAC-Seq) to characterize gene regulatory patterns in CD4 T cells that are associated with anergy induction and Foxp3+ Treg generation. Candidate gene regulators are being interrogated within neonatal mice--a time at which peripheral tolerance induction is essential for the avoidance of autoimmunity.
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The Journal of experimental medicineno. 12 (2023)
B. Raposo, M. Gomes Afonso,L. Israelsson,R. Stalesen, H. Wahamaa, M. Hansson,A. Hensvold,F. Wermeling,D. Mueller,B. Rethi,C. Gronwall,L. Klareskog,
Clare S. Hardman,Yi-Ling Chen,Marcin Wegrecki,Soo Weei Ng, Robert Murren, Davinderpreet Mangat,John-Paul Silva,Rebecca Munro,Win Yan Chan,Victoria O’Dowd,Carl Doyle,Prashant Mori,
ARTHRITIS & RHEUMATOLOGY (2022): 21-22
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Journal of Clinical Oncologyno. 16 (2022): 4107-4107
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JOURNAL OF IMMUNOLOGYno. 1 (2022)
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