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Bio
Dr. Brat directs a basic and translational research lab that investigates mechanisms of glioma progression, including the contributions of hypoxia, genetics, tumor microenvironment and stem cells. Glioma progression is characterized by tumor necrosis, severe hypoxia and angiogenesis. One project investigates mechanisms that cause hypoxia and has focused on vaso-occlusion and intravascular thrombosis that are thought to be initiated by tissue factor, a highly potent pro-coagulant. His lab is studying how the reshaping of the tumor micro-environment leads to accelerated tumor growth and how the enrichment of glioma stem cells and influx of tumor associated macrophages may promote this.
Research Interests
Papers共 438 篇Author StatisticsCo-AuthorSimilar Experts
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Cancersno. 9 (2024): 1753
Aida Rashidi,Leah K. Billingham,Andrew Zolp,Tzu-yi Chia,Caylee Silvers, Joshua L. Katz,Cheol H. Park, Suzi Delay,Lauren Boland,Yuheng Geng,Steven M. Markwell,Crismita Dmello,
Cellsno. 10 (2024): 823
Cancer researchno. 9 (2024): 1379-1381
Brain Pathology (2024)
Alexander S. Chen,Joanna Wardwell-Ozgo, Nilang N. Shah, Deidre Wright,Christina L. Appin,Krishanthan Vigneswaran,Daniel J. Brat,Harley I. Kornblum,Renee D. Read
crossref(2023)
Victor Karwacinski,Tatiana Carneiro-Lobo,Cheryl L. Olson, Marco Constante,Pinar Mesci,Daniel J. Brat,Alysson R. Muotri
Neuro-oncologyno. Supplement_5 (2023): v283-v284
Subhas Mukherjee,Carol Tucker-Burden,Changming Zhang,Kenneth Moberg,Renee Read, Costas Hadjipanayis,Daniel J. Brat
crossref(2023)
Giulia Fulci,Nina Dmitrieva,Davide Gianni, Elisabeth J. Fontana,Xiaogang Pan,Yanhui Lu, Claire S. Kaufman,Balveen Kaur,Sean E. Lawler,Robert J. Lee,Clay B. Marsh,Daniel J. Brat,
crossref(2023)
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