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Sight is our most precious sense. Diseases of the retina, like macular degeneration and glaucoma cause blindness and are among the top 10 disabilities affecting people. Macular degeneration results in death of photoreceptors, while glaucoma results in optic nerve degeneration and death of retinal ganglion cells. Although there are a number of approaches to restoring sight to people suffering from these diseases, we think a regenerative approach would be best. Unfortunately, mammals do not normally regenerate retinal neurons or optic axons. However, hope comes from the observation that teleost fish, like zebrafish, have remarkable regenerative abilities and can regenerate a damaged retina and optic nerve. Because the zebrafish and mammalian retina share structure and function, we suspect that mechanisms driving retina and optic nerve regeneration in zebrafish will suggest regenerative strategies that can be applied to mammals.
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论文共 100 篇作者统计合作学者相似作者
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Annual review of genetics (2024)
Development (Cambridge, England) (2024)
Kanagaraj Palsamy,Jessica Y Chen,Kaia Skaggs, Yusuf Qadeer, Meghan Connors,Noah Cutler,Joshua Richmond,Vineeth Kommidi, Allison Poles,Danielle Affrunti,Curtis Powell,Daniel Goldman,
Gliano. 11 (2023): 2642-2663
Palsamy Kanagaraj,Jessica Y. Chen,Kaia Skaggs, Yusuf Qadeer, Meghan Connors,Noah Cutler,Joshua Richmond,Vineeth Kommidi, Allison Poles,Danielle Affrunti,Curtis Powell,Daniel Goldman,
bioRxiv (Cold Spring Harbor Laboratory) (2022)
Journal of the American Association for Laboratory Animal Science : JAALASno. 2 (2020): 148-155
Palsamy Kanagaraj,Jessica Y. Chen,Kaia Skaggs, Yusuf Qadeer, Meghan Connors,Noah Cutler,Joshua Richmond,Vineeth Kommidi, Allison Poles,Danielle Affrunti,Curtis Powell,Daniel Goldman,
crossref(2020)
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