基本信息
浏览量:9
职业迁徙
个人简介
Dr. Cramer's research focuses on the epidemiology of ovarian cancer with the goal of developing a model to explain risk factors for the disease and biomarkers that might correlate with risk. There are three events which increase risk for ovarian cancer that are associated with chronic inflammation affecting the lower or upper genital tract. These include: cosmetic talc powder use; repeated ovulation not interrupted by pregnancies, breastfeeding, or oral contraceptive use (incessant ovulation), and endometriosis. Besides pregnancies, breastfeeding, and oral contraceptive use that decrease ovulations, other factors that lower risk for ovarian cancer include childhood mumps, a tubal ligation, and an infection while breastfeeding (mastitis). We have assembled data to suggest that the mucin tumor biomarkers CA125(MUC16) and CA15.3(MUC1) and immune reactions related to these may be unifying biomarkers. These mucins reside on the apical surfaces of the reproductive, digestive, and genital tracts as well as breast ducts. Acute events like mumps, tubal ligation, and mastitis lead to the spillage of tumor-like forms of MUC1 and MUC16 and the production of anti-mucin antibodies that could serve to protect against mucin-secreting ovarian tumors. Conversely chronic events like talc use, incessant ovulation, and endometriosis lead to prolonged exposure to mucins, down regulation of mucin immunity, and tolerance of an emerging mucin-secreting tumor.
研究兴趣
论文共 416 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Laura Wollborn,James W. Webber, Sudhanshu Mishra, Chad B. Sussman, Cameron E. Comrie, Daniel G. Packard,Allison Vitonis,Stephanie Alimena, Ryan Phan, Todd Pappas,Daniel W. Cramer,Dipanjan Chowdhury,
Linah Al-Alem,Jillian M. Prendergast,Justin Clark, Bianca Zarrella, Dominique T. Zarrella,Sarah J. Hill,Whitfield B. Growdon,Venkatesh Pooladanda,David R. Spriggs,Daniel Cramer,Kevin M. Elias, Rawan I. Nazer,
Journal of Ovarian Researchno. 1 (2024): 1-16
James W. Webber, Laura Wollborn, Sudhanshu Mishra,Allison Vitonis,Daniel W. Cramer, Ryan Phan, Todd Pappas,Dipanjan Chowdhury,Kevin M. Elias
CANCER RESEARCHno. 5 (2024)
CANCER PREVENTION RESEARCHno. 1 (2023)
引用0浏览0引用
0
0
crossref(2023)
crossref(2023)
Albina N. Minlikeeva,Jo L. Freudenheim,Kevin H. Eng,Rikki A. Cannioto, Grace Friel,J. Brian Szender,Brahm Segal,Kunle Odunsi,Paul Mayor,Brenda Diergaarde,Emese Zsiros,Linda E. Kelemen,
crossref(2023)
Cancer Prevention Researchno. 1_Supplement (2023): P030-P030
crossref(2023)
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn