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个人简介
The Bogenhagen laboratory has had a role in defining the basic mechanisms of mitochondrial DNA (mtDNA) replication, transcription and repair in animal cells. All of the proteins involved in these critically important processes, over 200 in number, are encoded by nuclear genes whose protein products are imported into mitochondria. Our work has involved efforts to map promoters for transcription of mtDNA and to characterize mitochondrial DNA polymerase g, mtRNA polymerase, the architectural transcription factor TFAM and other accessory proteins. We were among the first to purify pol g, mtRNA polymerase and transcription factor TFBM2. In collaboration with the Kisker laboratory, we determined the crystal structure of the pol g accessory factor polgB and its relationship to the EM structure of the holoenzyme. We were also the first laboratory to reconstitute base excision repair using purified mitochondrial proteins.
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Nehaben A Gujarati, Alexandra R Leonardo,Jessica M Vasquez,Yiqing Guo, Bismark O Frimpong,Elbek Fozilov,Monica P Revelo,Ilse S Daehn,John C He,Daniel Bogenhagen,Sandeep K Mallipattu
Diabetesno. 1 (2021)
The Journal of biological chemistryno. 9 (2020): 2544-2554
Changwan Ryu,Huanxing Sun,Mridu Gulati,Jose D Herazo-Maya,Yonglin Chen,Awo Osafo-Addo,Caitlin Brandsdorfer,Julia Winkler, Christina Blaul, Jaden Faunce,Hongyi Pan,Tony Woolard,
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