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个人简介
Daniel Abankwa is Professor for Cancer Cell Biology at the University of Luxembourg. He studied chemistry and biology in Göttingen (Germany), and completed his PhD in molecular neurobiology in Düsseldorf (Germany). In 2002, he moved as a postdoc to the EPFL in Switzerland, before he started working on the oncogene RAS with Prof. John Hancock at the Institute for Molecular Bioscience of the University of Queensland (Australia) in 2006. He then became junior group leader with Prof. Kirill Alexandrov at the same institute in 2008, before he moved as adjunct professor to the Turku Centre for Biotechnology/ Turku Bioscience Centre (Finland) in 2010.
Daniel' research focuses on understanding how the different RAS isoforms impact mechanistically on cancer cell stemness and how this can be exploited for drug targeting of RAS. Early in his RAS career, he provided pioneering Fluorescence Resonance Energy Transfer (FRET)-data supporting that RAS undergoes biologically significant conformational transitions in the plasma membrane. Daniel is an expert in studying RAS nanocluster, which are signaling hubs of RAS in the membrane. His group employs quantitative fluorescence imaging, flow cytometry, biochemical and cellular assay development and molecular cell biology. They developed several FRET- and BRET-biosensors for the detection of functional membrane anchorage of small GTPases and Src-family proteins, as well as for various interactions in the RAS pathway. Recently, several drug development projects were launched against RAS surrogate targets employing in silico screening, classical small molecules, protein-protein interface targeting small molecules and peptides/ peptidomomimetics.
研究兴趣
论文共 94 篇作者统计合作学者相似作者
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Pelin Kaya,Elisabeth Schaffner-Reckinger,Ganesh Babu Manoharan, Vladimir Vukic, Alexandros Kiriazis, Mirko Ledda, Maria Burgos Renedo,Karolina Pavic,Anthoula Gaigneaux,Enrico Glaab,Daniel Kwaku Abankwa
Journal of medicinal chemistryno. 11 (2024): 8569-8584
Pelin Kaya,Rohan Chippalkatti,Elisabeth Schaffner-Reckinger, Bianca Parisi,Ganesh B. Manoharan, Yashar Rouzbahani,Christian Eggeling,Daniel Abankwa
Cancer Researchno. 7_Supplement (2023): 3493-3493
STAR PROTOCOLSno. 4 (2023): 102637-102637
Pelin Kaya,Rohan Chippalkatti,Elisabeth Schaffner-Reckinger, Bianca Parisi, Ganesh B. Manoharan, Yashar Rouzbahani,Christian Eggeling,Daniel Abankwa
CANCER RESEARCHno. 7 (2023)
bioRxiv (Cold Spring Harbor Laboratory) (2023)
Single Molecule Spectroscopy and Superresolution Imaging XVI (2023)
Rohan Chippalkatti, Bianca Parisi, Farah Kouzi, Christina Laurini, Nesrine Ben Fredj,Daniel Kwaku Abankwa
European Journal of Cell Biologyno. 2 (2023): 151425-151425
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