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Bio
The Wagenaar Lab studies the neuronal basis of sensory processing and sensory-guided behavior, with a specific focus on crossmodal sensory integration in the leech and on functional and anatomical circuit mapping. The relatively simple nervous system of the European medicinal leech is perfectly suited to develop insights about how the activity of all the cells in a nervous system together produce individual behaviors from overlapping functional networks, a phenomenon that—at a much larger scale and undoubtedly with many complexities added—is also crucial to human brain function.
In the leech, we can:
Use voltage-sensitive dyes (VSDs) to record simultaneously from the vast majority of neurons in a functional unit of the nervous system during production of several behaviors (including swimming, crawling, and escape responses);
Use serial blockface scanning electron microscopy (SBEM) to determine connectivity between the neurons in this functional unit;
Combine these imaging modalities to gain insight into the relationship between structural elements such as circuit motifs and the behavioral functionality of neuronal networks.
In the leech, we can:
Use voltage-sensitive dyes (VSDs) to record simultaneously from the vast majority of neurons in a functional unit of the nervous system during production of several behaviors (including swimming, crawling, and escape responses);
Use serial blockface scanning electron microscopy (SBEM) to determine connectivity between the neurons in this functional unit;
Combine these imaging modalities to gain insight into the relationship between structural elements such as circuit motifs and the behavioral functionality of neuronal networks.
Research Interests
Papers共 68 篇Author StatisticsCo-AuthorSimilar Experts
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期刊级别
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bioRxiv (2021)
The Journal of Neurosciencepp.1-26, (2020)
Social Science Research Network (2020)
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Author Statistics
#Papers: 68
#Citation: 3499
H-Index: 25
G-Index: 52
Sociability: 5
Diversity: 2
Activity: 15
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