基本信息
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职业迁徙
个人简介
Description of Research Expertise
Inflammation.
Inflammation has a profound effect on the connective tissue, causing its resorption and limiting repair of damaged structures. I am interested in how cytokines regulate inflammation and cell death including the activation of transcription factors that globally affect pro-apoptotic gene expression. These studies involve the use of specific inhibitors of apoptosis and cytokines as well as mice with targeted genetic deletions to study their functional role in repair of injured connective tissue and bone.
Diabetes.
Diabetes-associated cytokine dysregulation may represent a common link in a number of diabetic complications including retinopathy and impaired wound healing. A limited ability to repair lost tissue may also represent a mechanism for greater net loss of bone and connective tissue in diabetes-enhanced periodontal disease and impaired fracture healing in diabetics. My laboratory is investigating mechanisms through which these processes are affected by diabetes via altered transcription factor activity and cytokine dysregulation.
Inflammation.
Inflammation has a profound effect on the connective tissue, causing its resorption and limiting repair of damaged structures. I am interested in how cytokines regulate inflammation and cell death including the activation of transcription factors that globally affect pro-apoptotic gene expression. These studies involve the use of specific inhibitors of apoptosis and cytokines as well as mice with targeted genetic deletions to study their functional role in repair of injured connective tissue and bone.
Diabetes.
Diabetes-associated cytokine dysregulation may represent a common link in a number of diabetic complications including retinopathy and impaired wound healing. A limited ability to repair lost tissue may also represent a mechanism for greater net loss of bone and connective tissue in diabetes-enhanced periodontal disease and impaired fracture healing in diabetics. My laboratory is investigating mechanisms through which these processes are affected by diabetes via altered transcription factor activity and cytokine dysregulation.
研究兴趣
论文共 212 篇作者统计合作学者相似作者
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Edmara T. P. Bergamo,Lukasz Witek,Ilana Santos Ramalho,Adolfo Coelho de Oliveira Lopes,Vasudev Vivekanand Nayak,Andrea Torroni,Blaire V. Slavin, Estevam A. Bonfante, Kathryn E. Uhrich,Dana T. Graves,Paulo G. Coelho
Science bulletinno. 9 (2023): 860-863
Bushra Alghamdi,Hyeran Helen Jeon,Jia Ni,Dongxu Qiu, Alyssia Liu, Julie J. Hong, Mamoon Ali, Albert Wang, Michael Troka,Dana T. Graves
Current Osteoporosis Reportsno. 2 (2023): 128-146
Bo Yang,Stella Alimperti,Michael V Gonzalez,Tzvete Dentchev, Minjung Kim, Justin Suh,Paul M Titchenell,Kang I Ko,John Seykora, Manju Benakanakere,Dana T Graves
Diabetes (2023)
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WOUND REPAIR AND REGENERATIONno. 2 (2023): 268-268
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Oelisoa M. Andriankaja,Kaumudi J. Joshipura, Michael A. Levine,Margarita Ramirez-Vick, Julio A. Rivas-Agosto, Jorge S. Duconge,Dana T. Graves
THERAPEUTIC ADVANCES IN CHRONIC DISEASE (2023)
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