My research in Oxford has been based on the study of cardiac structure, function and metabolism in normal and diseased hearts using MRI/MRS. This has included developing techniques using high spatial and temporal resolution CINE imaging to assess heart function and localized phosphorus and carbon spectroscopy to monitor and investigate abnormalities of metabolism. I have recently been awarded a British Heart Foundation Senior Research Fellowship to further develop the technique of Dynamic Nuclear Polarization (DNP) for application to the study of cardiac metabolism in the human heart. A fundamental limitation of magnetic resonance is its low sensitivity, but the recently developed technique of DNP provides a practical method to gain up to 10,000-fold increases in sensitivity in molecules with an in vivo stability of approximately one minute. This has enabled visualization of 13C-labelled cellular metabolites in vivo and, more importantly, their enzymatic transformation into other species. This is an important development that could revolutionize spectroscopy using MR.