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个人简介
Dr. Lawrence’s laboratory studies the role of proteases and their inhibitors in health and disease. Primary areas of interest focus on the vascular biology of the central nervous system (CNS) and disorders such as stroke, as well as the development of peripheral vascular disease.
He has over 25 years of experience in vascular biology and over 15 years of experience with animal models of stroke, and other CNS disorders. Studies range from very basic questions such as how binary protein interactions regulate physiologic processes to complex animal models of disease. The principal targets of this work are members of the serine protease inhibitor (serpin) family of proteins, their target proteases, including tissue plasminogen activator (tPA), and the downstream protease substrates. He uses combinations of biochemical, molecular, and genetic approaches to study how specific molecular interactions regulate function, and then applies this information to in vivo models of disease to test the importance of these interactions in complex physiologic processes.
He has over 25 years of experience in vascular biology and over 15 years of experience with animal models of stroke, and other CNS disorders. Studies range from very basic questions such as how binary protein interactions regulate physiologic processes to complex animal models of disease. The principal targets of this work are members of the serine protease inhibitor (serpin) family of proteins, their target proteases, including tissue plasminogen activator (tPA), and the downstream protease substrates. He uses combinations of biochemical, molecular, and genetic approaches to study how specific molecular interactions regulate function, and then applies this information to in vivo models of disease to test the importance of these interactions in complex physiologic processes.
研究兴趣
论文共 338 篇作者统计合作学者相似作者
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Joanna M. Cooper,Aurelien Lathuiliere,Enming J. Su, Yuyu Song,Daniel Torrente,Youhwa Jo, Nicholas Weinrich, Jennifer Diaz Sales,Mary Migliorini,Thomas H. Sisson,Daniel A. Lawrence,Bradley T. Hyman,
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICAno. 10 (2024): e2315083121-e2315083121
Phytopathologyno. 8 (2023): 1417-1427
Andreia Goncalves, Enming J. Su, Arivalagan Muthusamy, Manuel Zeitelhofer, Daniel Torrente, Ingrid Nilsson, Jil Protzmann, Linda Fredriksson, Ulf Eriksson,David A. Antonetti,Daniel A. Lawrence
BLOODno. 4 (2022): 388-400
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#Papers: 334
#Citation: 17374
H-Index: 73
G-Index: 124
Sociability: 7
Diversity: 4
Activity: 44
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