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Bio
Research in the Winge laboratory is focused on cellular mitochondria. One major focus is the biogenesis of the mitochondrial electron transfer respiratory complexes II, III and IV within this organelle. Improper assembly of these complexes are evident in inherited and acquired diseases of patients with cardiomyopathy, hepatopathy, and neurological disorders. A key step in assembly of these complexes is the formation of their essential flavin, heme, and iron-sulfur centers, which are inserted by the involvement of assembly factor proteins. Much of the current knowledge on the biogenesis of theses respiratory complexes was elucidated in Saccharomyces cerevisiae, and many of the known assembly factors are conserved in humans. Dr. Winge and his team seek to identify new proteins that mediate the biogenesis of succinate dehydrogenase, cytochrome c reductase and cytochrome c oxidase complexes, and then elucidate their mechanism of action. They use a combination of in vitro biochemical, in vivo cellular assays and genetic analyses in these pursuits. Specifically, they study how flavin and three iron-sulfur centers are formed in succinate dehydrogenase, how the heme andiron-sulfur centers are formed in cytochrome c reductase and the pathway of copper and heme a center formation in cytochrome oxidase. In these studies, research focuses on known assembly factors, as well as seeking novel factors that mediate formation of the redox centers.
Research Interests
Papers共 308 篇Author StatisticsCo-AuthorSimilar Experts
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Yeyun Ouyang, Mi-Young Jeong, Corey N Cunningham, Jordan A Berg, Ashish G Toshniwal, Casey E Hughes, Kristina Seiler, Jonathan G Van Vranken, Ahmad A Cluntun, Geanette Lam, Jacob M Winter, Emel Akdogan,
crossref(2023)
biorxiv(2022)
Metal Ions in Fungipp.279-310, (2020)
biorxiv(2020)
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