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Bio
David considers himself very fortunate both personally and professionally. He was affected seriously by rheumatic fever in very early life and was privileged to be treated with penicillin, then a prohibitively expensive item. When he was 12 years old, he saw, first hand, at the Sir William Dunn laboratories in Oxford where the drug was developed, the science which underpinned the development of antibiotics. This stimulated his interest not only in basic science but also its application to improving health outcomes. His PhD project was to determine the hepatic effects of insulin and fructose using the then-novel technique of organ perfusion. This was a very significant choice as it taught him the importance of ensuring that the experimental conditions should be as close to physiological as possible. His work at the Veterinary College focused on the role of a number of physiological and lifestyle factors on hepatic lipid and carbohydrate metabolism, principally in relation to heart disease risk. Tissue oxygen supply emerged as a key influencing factor on metabolism with implications for diabetes management, heart disease and cancer. This factor emerged as a prime contributor to greater disease risk in cigarette smokers.
Research Interests
Papers共 276 篇Author StatisticsCo-AuthorSimilar Experts
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semanticscholar(2019)
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Microbial Metabolomicspp.13-48, (2016)
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#Papers: 251
#Citation: 22089
H-Index: 60
G-Index: 146
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Diversity: 1
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