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个人简介
The laboratory is interested in understanding the mechanisms underlying the pathogenesis and immunoregulation of T cell-mediated autoimmune diseases, allergic disease, and rejection of tissue and organ transplants. In particular, we are studying the therapeutic use of short-term administration of costimulatory molecule agonists/antagonists and specific immune tolerance induced by infusion of antigen-coupled apoptotic cells and antigen-encsapsulating biodegradable PLG nanoparticles for the treatment of animal models of multiple sclerosis, neuromyelitis optica, and type 1 diabetes; allergic airway disease; as well as using tolerance for specific prevention of rejection of allogeneic and xenogeneic tissue and organ transplants. Recently, we have shown that PLG nanopartivle tolerance was safe in highly efficacious in a phase 1/2 clinical trial in celiac disease patients. The laboratory is also investigating the mechanisms of regulating acute inflammation using negatively charged PLG nanoparticles in models of traumatic and infectious inflammatory conditions and cancer.
研究兴趣
论文共 794 篇作者统计合作学者相似作者
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Gabriel Arellano,Eric Acuña,Eileah Loda, Lindsay Moore,Juan E. Tichauer,Cristian Castillo, Fabian Vergara,Paula I. Burgos,Pablo Penaloza-MacMaster,Stephen D. Miller,Rodrigo Naves
Journal of Neuroinflammationno. 1 (2024): 1-17
Michael N. Saunders,Laila M. Rad, Laura A. Williams,Jeffrey J. Landers,Russell R. Urie,Sarah E. Hocevar,Miguel Quiros,Ming-Yi Chiang, Amogh R. Angadi,Katarzyna W. Janczak,Elizabeth J. Bealer,Kelly Crumley,
JCI INSIGHTno. 1 (2024)
FRONTIERS IN CELLULAR NEUROSCIENCE (2024): 1321682-1321682
Huimin Jiang, Min Liu,Wending Yang,Yi-Kai Hong,Dan Xu, Elif Kayaalp Nalbant, Elwin D. Clutter, Parisa Foroozandeh,Nihal Kaplan,Jan Wysocki,Daniel Batlle,Stephen D. Miller,
iScienceno. 8 (2024): 110534
Journal of Immunologyno. 1 (2023): 166.06-166.06
Journal of Immunologyno. 1 (2023): 166.04-166.04
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作者统计
#Papers: 793
#Citation: 38593
H-Index: 104
G-Index: 171
Sociability: 8
Diversity: 1
Activity: 2
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