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Deepak Srivastava
Distinguished Professor
Srivastava Lab
Gladstone Institute of Cardiovascular Disease, University of California San Francisco;Department of Pediatrics, University of California San Francisco;Department of Biochemistry and Biophysics, University of California San Francisco
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基本信息
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Bio
Our laboratory focuses on understanding the causes of heart disease and on using knowledge of cardiac developmental pathways to devise novel therapeutic approaches for human cardiac disorders. Specifically, we study the molecular events regulating early and late developmental decisions that instruct progenitor cells to adopt a cardiac cell fate and subsequently fashion a functioning heart. We focus on transcriptional and post-transcriptional steps, including those involving microRNAs. We have leveraged this knowledge to reprogram fibroblasts directly into cardiomyocyte-like cells for regenerative purposes. We also seek to identify the causes of human cardiovascular disease by applying modern genetic technologies for the study of complex traits such as congenital heart disease. By using a spectrum of approaches including mouse and human genetics, molecular and developmental biology, and biochemistry we hope to develop a broad understanding of the biology underlying cardiogenesis and cardiovascular disorders.
Research Interests
Papers共 322 篇Author StatisticsCo-AuthorSimilar Experts
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Nature Cardiovascular Researchno. 3 (2024): 317-331
Circulation. Genomic and precision medicineno. 3 (2023): 224-231
Bonnie E J Maven,Casey A Gifford,Melanie Weilert,Barbara Gonzalez-Teran,Ruth Hüttenhain,Angelo Pelonero,Kathryn N Ivey,Kaitlen Samse-Knapp, Wesley Kwong,David Gordon,Michael McGregor,Tomohiro Nishino,
Stem cell reportsno. 11 (2023): 2138-2153
International immunopharmacology (2023): 109741-109741
NATURE CARDIOVASCULAR RESEARCHno. 12 (2023): 1127-1128
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