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The Pellman Lab works on the mechanism of cell division and how certain cell division errors drive rapid genome evolution. The normal processes studied in the laboratory have included spindle positioning and asymmetric cell division, the mechanism of spindle assembly and cytokinesis, and the mechanism of nuclear envelope assembly and how it is coordinated with chromosome segregation. The mutational processes studied in David’s group are particularly important for cancer, but have relevance for genome evolution in other contexts. Current projects include: the mechanism of a newly discovered mutational process called “chromothripsis”, how the architecture and integrity of the nuclear envelope impacts genome maintenance, and the role of cytoplasmic chromatin in triggering innate immune proinflammatory signaling. The lab uses a variety of approaches which include, molecular genetics, biochemistry, and imaging. Currently there is a heavy emphasis on using a combination of live-cell imaging and single-cell genome sequencing developed in the lab (“Look-Seq”) to relate the consequences of cell division errors to genome alterations.
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论文共 227 篇作者统计合作学者相似作者
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biorxiv(2024)
Cancer Researchno. 7_Supplement (2023): 6105-6105
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CANCER RESEARCHno. 7 (2023)
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Stamatis Papathanasiou, Nikos A. Mynhier,Shiwei Liu,Gregory Brunette,Ema Stokasimov,Etai Jacob, Lanting Li, Caroline Comenho,Bas van Steensel,Jason D. Buenrostro,Cheng-Zhong Zhang,David Pellman
Natureno. 7968 (2023): 184-192
Shannon Coy, Brian Cheng,Jong Suk Lee,Rumana Rashid, Lindsay Browning, Yilin Xu, Sankha S Chakrabarty,Clarence Yapp,Sabrina Chan,Juliann B Tefft, Emily Scott, Alexander Spektor,
bioRxiv : the preprint server for biology (2023)
Developmental Cellno. 10 (2023): 847-865.e10
crossref(2023)
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