Daniel M Cohen - Department of Thoracic Surgery, Children's Hospital

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Bio

Daniel M Cohen leads the Vector Optimization team at Spark Therapeutics, Inc.. This team explores how to overcome the traditional limits of AAV-based gene therapy using tools from synthetic and computational biology. In particular, we are interested in gene circuits that tune gene expression in response to environmental cues or based on cell identity.

Research Interests

Papers共 169 篇Author StatisticsCo-AuthorSimilar Experts

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Tunable Transgene Expression Using an ADAR-Mediated Gene Switch

Joseph Silverberg, Laura Pereira,Daniel M. Cohen,Federico Mingozzi,Sean M. Armour

MOLECULAR THERAPYno. 4 (2024): 775-776

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AAV-Mediated PPT1 Replacement and Cross Correction for Treating CLN1 Batten Disease

Suhail Alam, Apeksha Khatiwada,Daniel M. Cohen, Drew R. Peterson, John White, Melissa Derby, Bo Wang,Mohamad Nayal, Mallory Becker, Manju Benakanakere,Heena Beck, Charlie Li, Renee Gentzel, Jodi L. McBride,Maria Grazia Biferi,Elizabeth Ramsburg

MOLECULAR THERAPY（2024）

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Screening of Novel Liver-Directed Enhancers Using Pooled, Barcoded AAVs

Aditya Saxena, Yahui Lan, Perry Evans, Laura Pereira,Sean M. Armour,Daniel M. Cohen

MOLECULAR THERAPYno. 4 (2024): 694-694

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Expanding the Toolbox of Ubiquitous Promoters for Gene Therapy

Joseph Silverberg,Jang Hwan Cho,Mitul Patel,Nathan Youssef,Federico Mingozzi,Daniel M. Cohen,Sean M. Armour

MOLECULAR THERAPY（2023）

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HICOS: High-Throughput Screening of Codon Optimized Sequences Using Protein Barcoding

Jang Hwan Cho, Perry Evans,Mitul Patel, Pichai Raman,Federico Mingozzi,Sean M. Armour,Daniel M. Cohen

MOLECULAR THERAPYno. 4 (2023): 135-136

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Massively Parallel and Systematic Engineering Platform for Highly Compact, Cell-Type Specific, and Potent Smart Sensor Promoters for Precision Retinal Gene Therapies

Joseph Draut, Thant Zaw, Myles MacEachern,Magdalena Cichewicz,Assen Roguev,Jang Hwan Cho,Daniel M. Cohen, Laura Barrio Real,Shreyasi Choudhury, Ali Nahvi,Jed Chatterton,Virginia A. Haurigot,Sean M. Armour,Federico Mingozzi, Rocky Chueng,Michelle Hung,Frances Liu,Rebecca Cottman,Nicholas Frankel,Tony Hua,Gary K. Lee, Curt Herberts,Philip Lee,Timothy Lu,Russell Gordley

MOLECULAR THERAPYno. 4 (2023): 183-184

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Investigational Liver Gene Transfer of C1-INH for the Treatment of Hereditary Angioedema

C. R. Riling,F. Pankowicz,H. Hanby,M. Scriver,S. Ioele,V. Posternak-Ball,W. J. Quinn,D. M. Cohen, G. M. Preston,M. Crosariol,S. M. Armour,F. Mingozzi

HUMAN GENE THERAPY（2021）

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The Endopeptidase IdeS Degrades Anti-AAV IgG and Enables Liver-Directed AAV Gene Therapy in Animal Models of Humoral Immunity

J. M. Alexander, M. Jennis, K. See,H. Hanby,A. Li,D. Lupo, S. Muraleetharan, C. Rizzo,D. M. Cohen, J. Silverberg, H. Beck,X. M. Anguela,S. M. Armour,F. Mingozzi

HUMAN GENE THERAPY（2021）

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IdeS: an Enabling Technology to Overcome the Limitation of Neutralizing Antibodies to AAV Gene Therapy

Jeffrey M. Alexander,Hayley Hanby, Daniel Lupo,Saghana Muraleetharan, Christopher Rizzo,Daniel M. Cohen,Joseph Silverberg,Heena Beck,Xavier Anguela,Sean M. Armour,Federico Mingozzi

Molecular Genetics and Metabolism（2021）

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IgG-cleaving Endopeptidase Enables in Vivo Gene Therapy in the Presence of Anti-Aav Neutralizing Antibodies

Christian Leborgne,Elena Barbon,Jeffrey M. Alexander,Hayley Hanby,Sandrine Delignat,Daniel M. Cohen,Fanny Collaud,Saghana Muraleetharan, Dan Lupo,Joseph Silverberg,Karen Huang, Laetitia van Wittengerghe,Béatrice Marolleau, Adeline Miranda,Anna Fabiano,Victoria Daventure,Heena Beck,Xavier M. Anguela,Giuseppe Ronzitti,Sean M. Armour,Sebastien Lacroix-Desmazes,Federico Mingozzi

Nature medicine（2020）

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