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The overall goals of my research are to characterize bone marrow (BM) derived stem/progenitor cells, and to define the mechanisms that regulate the self-renewal and differentiation of these cells with the goal of improving therapeutic approaches to hematological diseases including leukemia. We have 2 major foci. The first is the molecular mechanism(s) regulating gene expression during normal and malignant hematopoiesis. We are using hematopoietic stem cells and human embryonic stem cells to better understand Acute Megakaryoblastic Leukemia. In vitro and in vivo cell and molecular approaches will help us to better understand hematopoiesis and leukemogenesis. The second focus is the differentiation of pluripotent stem cells to produce function parathyroid epithelial cells in order to develop effective cellular therapy for patients with hypoparathyroidism.
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Xuan Zhang,Baobao Song, Maximillian J. Carlino,Guangyuan Li,Kyle Ferchen, Mi Chen,Evrett N. Thompson,Bailee N. Kain, Dan Schnell,Kairavee Thakkar,Michal Kouril,Kang Jin,
Nature Immunologyno. 4 (2024): 1-13
Victor Olmos,Evrett N. Thompson,Neha Gogia,Kimberly Luttik, Vaishnavi Veeranki, Luhan Ni, Serena Sim, Kelly Chen,Diane S. Krause,Janghoo Lim
HUMAN MOLECULAR GENETICSno. 2 (2024): 138-149
Magdalena M. Coman,Lajos Pusztai,Regina Hooley, Liva Andreveja,Leah Kim,Nikhil Joshi,Alexey Bersenev,Diane Krause,Tristen S. Park
JOURNAL OF IMMUNOTHERAPYno. 2 (2024): 49-53
Experimental Hematology (2023): S104
Experimental hematology (2023): 36-44.e3
R. Gudneppanavar,C. Di Pietro, H. Oez, P. Zhang, P. Huang, C. Britto-Leon,D. Krause,M. Egan,T. Murray,E. Bruscia
Journal of Cystic Fibrosis (2023): S113-S113
Experimental Hematology (2023): S147-S147
EXPERIMENTAL HEMATOLOGY (2023): S96-S96
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