基本信息
views: 5
![](https://originalfileserver.aminer.cn/sys/aminer/icon/show-trajectory.png)
Bio
Research Interests: Neuropathology and Biomarkers of Neurodegenerative Disease.
Keywords: Neuropathology, Digital Pathology, Biomarkers, Frontotemporal degeneration, Primary progressive aphasia, Amyotrophic lateral sclerosis, Lewy body disorders, Parkinson's disease, Alzheimer's disease, tau, amyloid-beta, alpha-synuclein, TDP-43.
Research Details: In the Penn Digital Neuropathology Lab (DNPL), we use a multidisciplinary approach merging techniques in "wet-lab" based histopathology of human brain tissue with "dry-lab" based image analysis and bioinformatics tools with the overarching goal of improving our understanding of brain-behavior relationships and the antemortem diagnosis of neurodegenerative disease.
Currently, the diagnostic standard is neuropathological examination at autopsy, which is a major obstacle for clinical trials in neurodegenerative disease. To address this problem our approach is to "work backwards" to study human brain tissue and measure neuropathology objectively using novel open-source digital image analysis tools; We use a "tissue-guided biomarker discovery” method to translate our findings with the ultimate goal to develop new laboratory and imaging tests to detect pathology in living patients.
Keywords: Neuropathology, Digital Pathology, Biomarkers, Frontotemporal degeneration, Primary progressive aphasia, Amyotrophic lateral sclerosis, Lewy body disorders, Parkinson's disease, Alzheimer's disease, tau, amyloid-beta, alpha-synuclein, TDP-43.
Research Details: In the Penn Digital Neuropathology Lab (DNPL), we use a multidisciplinary approach merging techniques in "wet-lab" based histopathology of human brain tissue with "dry-lab" based image analysis and bioinformatics tools with the overarching goal of improving our understanding of brain-behavior relationships and the antemortem diagnosis of neurodegenerative disease.
Currently, the diagnostic standard is neuropathological examination at autopsy, which is a major obstacle for clinical trials in neurodegenerative disease. To address this problem our approach is to "work backwards" to study human brain tissue and measure neuropathology objectively using novel open-source digital image analysis tools; We use a "tissue-guided biomarker discovery” method to translate our findings with the ultimate goal to develop new laboratory and imaging tests to detect pathology in living patients.
Research Interests
Papers共 448 篇Author StatisticsCo-AuthorSimilar Experts
By YearBy Citation主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Cyril Pottier,Fahri Küçükali,Matt Baker,Anthony Batzler,Gregory D Jenkins,Marka van Blitterswijk,Cristina T Vicente,Wouter De Coster, Sarah Wynants, Pieter Van de Walle,Owen A Ross,Melissa E Murray,
medRxiv : the preprint server for health sciences (2024)
Pulkit Khandelwal,Michael Tran Duong, Lisa Levorse, Constanza Fuentes,Amanda Denning,Winifred Trotman,Ranjit Ittyerah, Alejandra Bahena,Theresa Schuck,Marianna Gabrielyan,Karthik Prabhakaran,Daniel Ohm,
arxiv(2024)
Cited0Views0Bibtex
0
0
George Kannarkat,Rebecca Zack, Robert Skrinak,James Morley,Roseanne Davila-Rivera,Sanaz Arezoumandan, Katherine Dorfman,Kelvin Luk,Daniel Weintraub,Thomas Tropea,Edward Lee,Virginia Lee,
Sadhana Ravikumar, Amanda E Denning,Sydney Lim,Eunice Chung, Niyousha Sadeghpour,Ranjit Ittyerah,Laura E M Wisse,Sandhitsu R Das,Long Xie,John L Robinson,Theresa Schuck,Edward B Lee,
Nature communicationsno. 1 (2024): 4803-4803
Marijne Vandebergh,Eliana Marisa Ramos,Nick Corriveau-Lecavalier,Vijay K Ramanan,John Kornak,Carly Mester, Tyler Kolander,Danielle Brushaber,Adam M Staffaroni,Daniel Geschwind,Amy Wolf,Kejal Kantarci,
medRxiv : the preprint server for health sciences (2024)
Peter S. Pressman, Danelle J. Carter,Eliana Marisa Ramos, Joie Molden, Kaitlin Smith, Francesca Dino,Corey McMillan,David Irwin,Katya Rascovsky,Nupur Ghoshal, Marguerite Knudtson,Rosa Rademakers,
NEUROCASEno. 1 (2024): 39-47
Imaging Neuroscience (2024)
Jeffrey Sevigny,Olga Uspenskaya, Laura Dean Heckman,Li Chin Wong, Daniel A. Hatch, Ambika Tewari,Rik Vandenberghe,David J. Irwin,Dario Saracino,Isabelle Le Ber,Rebekah Ahmed,Jonathan D. Rohrer,
NATURE MEDICINE (2024)
Load More
Author Statistics
Co-Author
Co-Institution
D-Core
- 合作者
- 学生
- 导师
Data Disclaimer
The page data are from open Internet sources, cooperative publishers and automatic analysis results through AI technology. We do not make any commitments and guarantees for the validity, accuracy, correctness, reliability, completeness and timeliness of the page data. If you have any questions, please contact us by email: report@aminer.cn