基本信息
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Bio
Dr. Ellison’s research centers on effects of diet on blood pressure, on mechanisms of salt transport by the kidney, on the genetic basis of human hypertension and on diuretic treatment of edema. A long-term focus of his research is the thiazide-sensitive NaCl cotransporter (NCC). His early studies helped define the distal convoluted tubule of the kidney and how mutations of NCC can lead to Gitelman syndrome. Dr. Ellison showed that the antibiotic trimethoprim causes hyperkalemia in humans by disrupting transport along the distal convoluted tubule and showed that chronic treatment with high doses of loop diuretics causes hypertrophy of the distal nephron, work that is now being translated to help improve diuretic treatment of edema. Dr. Ellison has been a leader in defining how mutations in a novel kinase pathway cause Familial Hyperkalemic Hypertension by altering distal salt transport and has defined how a high potassium diet reduces kidney salt transport. Finally, his group has demonstrated that the immunosuppressive drug tacrolimus causes hyperkalemia and hypertension by activating the NCC; this work has been translated to an ongoing clinical trial. All of his work melds basic and clinical approaches and has been published in top journals including Nature Medicine, the Journal of Clinical Investigation, Cell Metabolism, and the Journal of the American Society of Nephrology.
Research Interests
Papers共 165 篇Author StatisticsCo-AuthorSimilar Experts
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Journal of Clinical and Translational Scienceno. s1 (2024): 18-19
Physiologyno. S1 (2024)
Kidney360 (2024)
Kidney360no. 5 (2024): 768-770
Journal of Clinical and Translational Scienceno. s1 (2024): 155-155
Ryan Cornelius,Xiao-Tong Su,Jonathan Nelson,Jeremiah Reyes, Tanner Bradford,Chao-Ling Yang,David Ellison
PHYSIOLOGYno. S1 (2023)
Jeremiah Reyes,Xiao-Tong Su,Chao-Ling Yang, Paul Mark Medina,James McCormick,Jonathan Nelson,David Ellison
PHYSIOLOGYno. S1 (2023)
Journal of the American Society of Nephrologyno. 11S (2023): 546-547
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