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David Grimwade had a remarkable impact on the care of patients with acute myeloid leukaemia (AML) during his career. Possessing a skillset that combined clinical knowledge and expertise with a profound insight into the applicability of basic science to clinical medicine, he was in many ways the embodiment of the translational haematologist. Coupled with his exceptional generosity and tireless commitment to improving individual patient outcome, his career provided a compelling demonstration of the ever-expanding opportunities to improve patient outcomes through the application of science.
It was evident from early on during his research training that David would be able to combine that elusive aim for most clinician scientists, achieving advances in the basic science of leukaemia and in the process making a major contribution to the treatment of AML. His work led to influential publications on the importance of diagnostic cytogenetics on outcome in AML in addition to focussing on his research interests of the molecular pathogenesis of acute promyelocytic leukaemia (APL) and characterizing mechanisms underlying leukaemia-associated chromosomal translocations. He was among the first to characterize the PML-RAR fusion gene of APL and to track the fusion gene during therapy, working with international collaborators such as Francesco Lo Coco.
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论文共 218 篇作者统计合作学者相似作者
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Nigel Russell,Alan Burnett,Robert Hills, Sophie Betteridge,Mike Dennis,Jelena Jovanovic,Richard Dillon,David Grimwade
BLOODno. 13 (2018): 1452-1454
BLOOD CANCER JOURNALno. 8 (2018): 68-68
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