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Bio
Dr. Greenberg was a founding member of the UW Department of Immunology and the Fred Hutch Program in Immunology, helping develop productive training and research environments for investigators involved in basic immunology and translational cancer immunology research. Internationally recognized as a leader in the cancer immunology field, he has trained more than 40 investigators who have gone on to develop independent research careers, including many who have also become leaders in immunology fields. His laboratory performed some of the earliest studies on how immune T cells can recognize and eliminate malignant cells in the context of progressing tumors.
First using small animal models, the Greenberg lab developed technologies to produce functional, protein target (antigen)-specific T cells.
In the early 1990s, Dr. Greenberg and colleagues showed that T cells collected from human peripheral blood can be used to generate antigen-specific T cells in the lab, and that such T cells can then be reinfused into patients to seek and destroy diseased cells. He was a leader of the first group to formally demonstrate that such ‘adoptively’ transferred antigen-specific T cells can recognize and eradicate disseminated cancer cells. Dr. Greenberg’s team went on to clarify the requirements for T cells to persist and completely eliminate tumors. These early studies also revealed what was then a very surprising finding; i.e., that one type of tumor antigen-specific T cells (CD4+) can not only help the type of T cells (CD8+) that are best known for directly killing tumor cells but can also help eradicate disseminated tumors even without CD8+ T cells.
Dr. Greenberg’s findings initially led to approaches to protect immune-compromised patients from cytomegalovirus infections and to enhance control of HIV infections, which are both major causes of disease and mortality worldwide. More recently, his team has developed anti-cancer therapies using naturally isolated or genetically-engineered T cells. His lab continues to innovate using molecular strategies to create T cells that can show sustained function despite obstacles posed by progressive tumors.
Research Interests
Papers共 546 篇Author StatisticsCo-AuthorSimilar Experts
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Carolyn Shasha,David R Glass, Ernest Moelhman,Laura Islas, Yuan Tian,Gregory L Szeto, Tao Peng,Xiaoling Song, Michelle Wurscher,Thomas F Bumol,Troy R Torgerson,Philip D Greenberg,
bioRxiv : the preprint server for biology (2024)
Yuta Asano,Joshua Veatch,Megan McAfee, Jakob Bakhtiari,Bo Lee,Lauren Martin,Shihong Zhang,Francesco Mazziotta,Kelly G Paulson,Thomas M Schmitt, Ariunnaa Munkbhat, Cecilia Young,
medRxiv : the preprint server for health sciences (2024)
Zackery A. Ely, Zachary J. Kulstad,Eva K. Verzani,Jennifer G. Abelin, Sudarsana Addepalli,Karl R. Clauser, Marta Casarrubios,Kevin S. Kapner, Miles P. Agus,Connor J. Hennessey, Sine R. Hadrup,Susan Klaeger,
CANCER RESEARCHno. 2 (2024)
Sasha Gupta,Tijana Martinov, Ashley Thelen, Megumi Sunahara, Elaine Schanzer,Fyodor Urnov,Alexander Marson,Brian Shy,Philip Greenberg,Michael Wilson
Cancer Researchno. 7_Supplement (2024)
Allison Drain,Nicholas Rouillard,Nathaniel Swanson, Martina Canestraro,Santosh Narayan,Tyler Warner,Nicole Danek,Ken Gareau,Jinsheng Liang, Luhua Shen,Tanya Tetrault,Iqraa Priyata,
Cancer Researchno. 6_Supplement (2024): 9-9
Santosh Narayan,Ken Gareau,Ankit Gupta, Josh Ferrell,Nicholas Rouillard,Tyler Warner,Jinsheng Liang, Luhua Shen,Tanya Tetrault,Joshua Francis,Xingyue He,Patrick J. Browne,
Cancer Researchno. 6_Supplement (2024): 10-10
Elena G. Chiorean,Aude Chapuis,Andrew Coveler,Cecilia Yeung,Ted Gooley,David B. Zhen,Gentry King,Stacey Cohen,Lindsay Hannan, Rachael Safyan, Anthony Germani,Susan Ra,
CANCER RESEARCHno. 2 (2024)
Kristin G. Anderson,Yapeng Su,Madison G. Burnett,Breanna M. Bates, Magdalia L. Rodgers Suarez,Susan L. Ruskin,Valentin Voillet,Raphael Gottardo,Philip D. Greenberg
BLOOD (2023)
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