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The emphasis of our research has always been on spermatogonial multiplication and especially on the spermatogonial stem cells (SSCs). SSCs are at the basis of the multiplication process ensuring a life-long production of sperm. These cells are localized in a stem cell niche in which their maintenance is kept secure. Presently, we are developing a computer model for the behaviour of SSCs in- and outside of the niche. Understanding how the niche is regulated is important as depletion of SSCs will lead to sterility while too much self-renewal of SSCs will lead to the formation of a tumour. Knowledge of the regulatory mechanisms operating in the niche may give tools to help in particular cases of male infertility.
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论文共 314 篇作者统计合作学者相似作者
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Benjamin W. Walters, Shannon R. Rainsford, Rachel A. Heuer,Nicolas Dias,Xiaofang Huang,Dirk de Rooij,Bluma J. Lesch
Development (Cambridge, England)no. 10 (2023)
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bioRxiv : the preprint server for biology (2023)
Gina E. Merges,Lena Arevalo, Andjela Kovacevic,Keerthika Lohanadan,Dirk G. de Rooij, Carla Simon,Melanie Jokwitz,Walter Witke,Hubert Schorle
DEVELOPMENTno. 21 (2023)
Benjamin William Walters, Shannon R Rainsford,Nicolas Dias,Xiaofang Huang,Dirk G de Rooij,Bluma J Lesch
biorxiv(2022)
biorxiv(2021)
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