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Dr. Goldberg does basic research on the biology of malaria and identification of drug targets. Parasites have evolved many clever ways to infect their hosts and develop within them. Researching these processes at a molecular level should lead to treatment or prevention of parasitic infections that afflict most of humanity. His laboratory currently has 4 graduate students, 2 postdocs, one pediatric ID fellow, one technician and a research associate professor. Dr. Goldberg directs the Infectious Diseases/Basic Microbial Mechanisms T32 training grant.
Intraerythrocytic malaria parasites are fascinating creatures. They have evolved many clever strategies for survival inside their host cell. Most of these adaptations are still biological mysteries. Indeed, nearly half of the Plasmodium proteome comprises proteins of unknown function. Some are species or phylum specific; others have orthologs spread widely through phylogeny. We are interested in defining the roles of such proteins, with a special focus on proteases of unknown function. We use a combination of genetic and biochemical approaches to elucidate biological roles. To help us with this analysis, we have developed a regulated protein knockdown system for the study of essential proteins. This has allowed us to define a role for Plasmodium calpain in nucleolar control of cell cycle progression and a role for the aspartic protease plasmepsin V in export of parasite proteins to the host erythrocyte.
Intraerythrocytic malaria parasites are fascinating creatures. They have evolved many clever strategies for survival inside their host cell. Most of these adaptations are still biological mysteries. Indeed, nearly half of the Plasmodium proteome comprises proteins of unknown function. Some are species or phylum specific; others have orthologs spread widely through phylogeny. We are interested in defining the roles of such proteins, with a special focus on proteases of unknown function. We use a combination of genetic and biochemical approaches to elucidate biological roles. To help us with this analysis, we have developed a regulated protein knockdown system for the study of essential proteins. This has allowed us to define a role for Plasmodium calpain in nucleolar control of cell cycle progression and a role for the aspartic protease plasmepsin V in export of parasite proteins to the host erythrocyte.
Research Interests
Papers共 238 篇Author StatisticsCo-AuthorSimilar Experts
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crossref(2024)
Nature Communicationsno. 1 (2024): 1-18
Science translational medicineno. 686 (2023)
bioRxiv (Cold Spring Harbor Laboratory) (2023)
ACS infectious diseasesno. 4 (2023): 1004-1021
Analytica Chimica Acta (2023): 341226
Suong T. Nguyen, Daniel Du, Daniel Wychrij,Matthew D. Cain, Qingping Wu,Robyn S. Klein,Ilaria Russo,Daniel E. Goldberg
Proceedings of the National Academy of Sciences of the United States of Americano. 26 (2023)
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Author Statistics
#Papers: 237
#Citation: 17894
H-Index: 69
G-Index: 130
Sociability: 7
Diversity: 0
Activity: 1
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