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个人简介
I am a protein engineer and cell biologist whose research career has focused on cellular signalling and the use of affinity reagents for studying protein function. I graduated with a BSc in Biomedical Sciences from the University of Hull, UK in 1999 and completed my PhD in developmental biology in 2002. After a postdoctoral position (2002-2010) in the Leeds Institute of Molecular Medicine at the University of Leeds working with Prof Margaret Knowles on FGFR function in bladder cancer, I move to the School of Molecular and Cellular Biology at the same University to work with Professor Michael McPherson. As part of the Biomedical Health Centre I was involved in setting up two state of the art screening platforms; an siRNA and an affinity reagent screening facility. Here, I was involved in establishing the Affimer platform which was patented and licensed to Avacta Life Sciences. In 2015 I was awarded a University Academic Fellowship to use Affimers for studying cancer proteins, and in 2018 I was promoted to Associate Professor. My current research in focusing on using Affimers to study protein function to identify new biological process and novel protein conformations. My current focus is on using Affimers to study oncoproteins and proteins that confer bacterial resistance to antibiotics. I have published over 50 peer-reveiwed articles with a H-index of 24. As well as national departmental seminars, I have delivered over 25 international invited lectures.
研究兴趣
论文共 148 篇作者统计合作学者相似作者
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Yazan S. Khaled,M. Ibrahim Khot,Radhika Aiyappa-Maudsley,Thomas Maisey,Arindam Pramanik,Jim Tiernan, Nicole Lintern, Eiman Al-Enezi,Shazana H. Shamsuddin,Darren Tomlinson,Louise Coletta,Paul A. Millner,
NANOSCALEno. 14 (2024): 7185-7199
SENSORS & DIAGNOSTICSno. 1 (2024): 104-111
Yazan S Khaled,M Ibrahim Khot,Radhika Aiyappa-Maudsley,Thomas Maisey,Arindam Pramanik,Jim Tiernan, Nicole Lintern, Eiman Al-Enezi,Shazana H Shamsuddin,Darren Tomlinson,Louise Coletta,Paul A Millner,
Nanoscale (2024)
Rui-Gang Xu,Christian Tiede,Antonio N Calabrese,Lih T Cheah,Thomas L Adams,Julia S Sandrin Gauer,Matthew S Hindle, Beth A Webb, Daisie Madison Yates,Alexandre Slater,Cedric Duval,Khalid M Naseem,
Blood advances (2024)
Cell reportsno. 10 (2023): 113184-113184
The Journal of biological chemistryno. 11 (2023): 105325-105325
Biosensors & bioelectronics (2023): 115488-115488
Oliver Debski-Antoniak,Alex Flynn,David P. Klebl,Christian Tiede,Ian A. Wilson,Stephen P. Muench,Darren Tomlinson,Juan Fontana
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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