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The genomic sequences of humans, several eukaryotic model organisms, and numerous bacteria have opened up new opportunities and challenges for molecular genetics. Now one can study all the genes of an organism at once, promising a level of biological inference at the "system level", beyond that possible from studying separate, individual genes, gene assemblies or pathways. A major challenge is the analysis and display of huge volumes of information in ways that allow biologists to fully interpret them.
Research areas: (1) genome-wide studies of gene expression through the life cycle and experimental evolution of budding yeast (Saccharomyces cerevisiae), (2) mechanisms by which yeast maintain metabolic homeostasis in the face of environmental and genetic perturbations, and (3) quantitative analysis and intuitive display of genome-scale biological information in the context of genomic databases.
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Science advancesno. 21 (2023)
Michelle Chan,Han Yuan,Ilya Soifer,Tobias M Maile,Rebecca Y Wang,Andrea Ireland, Jonathon J O'Brien,Jérôme Goudeau, Leanne JG Chan,Twaritha Vijay,Adam Freund,Cynthia Kenyon,
crossref(2021)
biorxiv(2021)
Patrick A Gibney,Ariel Schieler,Jonathan C Chen, Jessie M Bacha-Hummel, Maxim Botstein,Matthew Volpe,Sanford J Silverman,Yifan Xu,Bryson D Bennett,Joshua D Rabinowitz,David Botstein
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