基本信息
views: 66
Career Trajectory
Bio
Artificial proteins represent a new class of macromolecular materials that bridge the gap that has traditionally separated natural polymers from their synthetic counterparts. While synthetic polymers are interesting and enormously important, their utility derives in large part from their physical properties; chemists have yet to capture in synthetic polymers the more subtle catalytic and informational properties of proteins and nucleic acids. The reason for this distinction lies in the levels of architectural control to be found in each class of polymers; proteins and nucleic acids are characterized by defined lengths, sequences, and stereochemistries, while synthetic polymers are highly heterogeneous molecular mixtures. This raises interesting questions about the kinds of novel science and engineering that could be done if new macromolecular architectures could be created with precise control of the most important structural variables.
Microbial expression of artificial genes provides a means of doing just that. The process begins with molecular design--the specification of a chain structure that the investigator believes will exhibit interesting (and perhaps useful) behavior. The target structure is then encoded into an artificial gene, and the gene is expressed in an appropriate microbial host. Current targets include reversible hydrogels and artificial extracellular matrices for use in tissue regeneration and repair.
Microbial expression of artificial genes provides a means of doing just that. The process begins with molecular design--the specification of a chain structure that the investigator believes will exhibit interesting (and perhaps useful) behavior. The target structure is then encoded into an artificial gene, and the gene is expressed in an appropriate microbial host. Current targets include reversible hydrogels and artificial extracellular matrices for use in tissue regeneration and repair.
Research Interests
Papers共 509 篇Author StatisticsCo-AuthorSimilar Experts
By YearBy Citation主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Journal of Biological Chemistryno. 6 (2024): 107332-107332
Chenxi Qian, Hanwei Liu, Priya K. Chittur, Rahuljeet S. Chadha,Yuxing Yao,Julia A. Kornfield,David A. Tirrell,Lu Wei
STEM CELLSno. 4 (2024): 385-401
Grace Z. Wang,Elizabeth A. Warren,Allison L. Haas, Andrea Sánchez Peña,Megan R. Kiedrowski,Brett Lomenick,Tsui-Fen Chou,Jennifer M. Bomberger,David A. Tirrell,Dominique H. Limoli
bioRxiv the preprint server for biology (2023)
Mark T. T. Kozlowski,Heather N. N. Zook, Desnor N. N. Chigumba, Christopher P. P. Johnstone, Luis F. F. Caldera,Hung-Ping Shih,David A. A. Tirrell,Hsun Teresa Ku
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2023): 1144209-1144209
ACS chemical biologyno. 12 (2023): 2574-2581
bioRxiv (Cold Spring Harbor Laboratory) (2022)
Load More
Author Statistics
Co-Author
Co-Institution
D-Core
- 合作者
- 学生
- 导师
Data Disclaimer
The page data are from open Internet sources, cooperative publishers and automatic analysis results through AI technology. We do not make any commitments and guarantees for the validity, accuracy, correctness, reliability, completeness and timeliness of the page data. If you have any questions, please contact us by email: report@aminer.cn