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The heterocyclic bases of DNA and RNA are subject to chemical modification, either accidentally or on purpose. For example, endogenous oxidative stress or external agents such as radiation lead to oxidation of the guanine base in both DNA and RNA. In DNA, this process is traditionally thought to be mutagenic, and an accumulation of mutations can lead to cancer. We recently demonstrated that oxidized bases can also be epigenetic, particularly in G-rich gene promoters where they impact gene expression via the base excision repair pathway.
The heterocyclic bases of DNA and RNA are subject to chemical modification, either accidentally or on purpose. For example, endogenous oxidative stress or external agents such as radiation lead to oxidation of the guanine base in both DNA and RNA. In DNA, this process is traditionally thought to be mutagenic, and an accumulation of mutations can lead to cancer. We recently demonstrated that oxidized bases can also be epigenetic, particularly in G-rich gene promoters where they impact gene expression via the base excision repair pathway.
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Papers共 445 篇Author StatisticsCo-AuthorSimilar Experts
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ISRAEL JOURNAL OF CHEMISTRYno. 3-4 (2024)
Alessia Bellina,Matilde Clarissa Malfatti, Gilmar Salgado,Aaron M. Fleming,Giulia Antoniali, Nicolò Gualandi,Sara La Manna,Daniela Marasco,Erik Dassi,Cynthia J. Burrows,Gianluca Tell
biorxiv(2024)
Alessia Bellina,Matilde Clarissa Malfatti, Gilmar Salgado,Aaron M. Fleming,Giulia Antoniali,Nicolò Gualandi,Sara La Manna,Daniela Marasco,Erik Dassi,Cynthia J. Burrows,Gianluca Tell
crossref(2024)
Aaron M Fleming,Cynthia J Burrows
Nucleic Acids Researchno. 4 (2023): 1914-1926
RSC Chemical Biologyno. 4 (2023): 261-270
bioRxiv (Cold Spring Harbor Laboratory) (2023)
Chemical communications (Cambridge, England)no. 58 (2023): 8997-9000
RSC chemical biologyno. 11 (2023): 952-964
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