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The properties of ultrathin polymer films are often different from their bulk counterparts. We use spin casting, Langmuir-Blodgett deposition, and surface grafting to fabricate ultrathin films in the range of 100 to 1000 Angstroms thick. Macromolecular amphiphiles are examined at the air-water interface by surface pressure, Brewster angle microscopy, and interfacial shear measurements and on solid substrates by atomic force microscopy, FTIR, and ellipsometry. A vapor-deposition-polymerization process has been developed for covalent grafting of poly(amino acids) from solid substrates. FTIR measurements permit study of secondary structures (right and left-handed alpha helices, parallel and anti-parallel beta sheets) as a function of temperature and environment.
A broadly interdisciplinary collaboration has been established with the Department of Ophthalmology in the Stanford School of Medicine. We have designed and synthesized a fully interpenetrating network of two different hydrogel materials that have properties consistent with application as a substitute for the human cornea: high water swellability up to 85%,tensile strength comparable to the cornea, high glucose permeability comparable to the cornea, and sufficient tear strength to permit suturing. We have developed a technique for surface modification with adhesion peptides that allows binding of collagen and subsequent growth of epithelial cells. Broad questions on the relationships among molecular structure, processing protocol, and biomedical device application are being pursued.
A broadly interdisciplinary collaboration has been established with the Department of Ophthalmology in the Stanford School of Medicine. We have designed and synthesized a fully interpenetrating network of two different hydrogel materials that have properties consistent with application as a substitute for the human cornea: high water swellability up to 85%,tensile strength comparable to the cornea, high glucose permeability comparable to the cornea, and sufficient tear strength to permit suturing. We have developed a technique for surface modification with adhesion peptides that allows binding of collagen and subsequent growth of epithelial cells. Broad questions on the relationships among molecular structure, processing protocol, and biomedical device application are being pursued.
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Papers共 681 篇Author StatisticsCo-AuthorSimilar Experts
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Eric D. Wachsman,Francois E.G. Henn, Nancy Jiang,Pieter B. Leezenberg, Richard Buchanan,Curtis W. Frank, David A. Stevenson, Joseph F. Wenckus
CRC Press eBookspp.584-592, (2023)
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Journal of materials chemistry. Bno. 34 (2023): 8159-8169
Jia-Yang Chen,Hsu-Huan Chou,Syer Choon Lim,Yen-Jang Huang, Kuan-Chen Lai,Chin-Lin Guo,Chien-Yi Tung,Chung-Tsai Su,Jocelyn Wang, Edward Liu,Hsiao-Fen Han,Po-Ying Yeh,
SPE Polymersno. 1 (2020): 15-25
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#Papers: 688
#Citation: 21745
H-Index: 74
G-Index: 116
Sociability: 7
Diversity: 0
Activity: 1
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