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个人简介
Cristina Moiteiro (CM) has graduated in Chemistry from Nova School of Science and Technology at the University of Lisbon (FCT/UNL), and Master and PhD degrees from FCT/UNL. Currently, CM is Assistant Researcher at Faculty of Sciences, University of Lisboa (FCUL) since January 2009. CM has focused her research in the medicinal chemistry towards the development of novel molecules of high therapeutic potential. First, at the National Institute of Engineering, Technology and Innovation I.P. (INETI), Department of Technology of Chemical Industries, CM started to develop Medicinal Chemistry research by introducing structural modifications of triterpenes with inhibitory activity against the growth of human tumours cell lines in vitro. Later, in collaboration with microbiology researchers, CM developed rifabutin derivatives that showed improved tuberculostatic activity against Mycobaterium tuberculosis H37Rv and multidrug-resistant Mycobaterium strains. Her group studied differential interactions of rifabutin analogues with human and bacterial membranes, as well as their implication for therapeutics and toxicity. Her group also developed diterpenoid compounds with anti-parasitic activity against Trypanosoma cruzi causing American trypanosomiasis (also known Chagas disease). Presently, at FCUL, as co-PI of the project "Anion transmembrane transport promoted by drug-like molecules: building a library of anion carriers inspired in Ataluren (PTC124)", her group synthesized an extensive library of anion transporters incorporating heteroaromatic rings and (thio)urea-binding groups. Presently, CM is involved in Medicinal Chemistry to carry out a project which aims to investigate and optimize a new library of compounds for their capacity to suppress premature termination codons (PTCs), in the CFTR gene so as to increase their therapeutic potential for the treatment of Cystic Fibrosis.
Natural Products is other areas of the interest, comprises the search of biopesticides for the mosquito dengue (Aedes) control. Mosquitoes are vectors of diseases like malaria, dengue and yellow fever, among other arboviruses. Search of essential oil (EO) constituents that affect insect’s behaviour, being potentially effective in pest control/pest management.
研究兴趣
论文共 50 篇作者统计合作学者相似作者
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Plants (Basel, Switzerland)no. 13 (2023): 2438-2438
Journal of Cystic Fibrosis (2023): S126-S127
Environmental Sciences Proceedingsno. 1 (2022): 21
Paulo Vieira,Margarida Q. Miranda,Igor Marques, Silvia Carvalho, Li-Jun Chen,Ethan N. W. Howe, Carl Zhen, Claudia Y. Leung,Michael J. Spooner, Barbara Morgado, Odete A. B. da Cruz e Silva,Cristina Moiteiro,
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作者统计
#Papers: 50
#Citation: 928
H-Index: 23
G-Index: 29
Sociability: 5
Diversity: 3
Activity: 2
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