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The research line of Dr. Cristina Costa focuses mainly on the development of cell- and tissue-based therapies using genetic engineering of the source cell for curing diseases caused by tissue loss or dysfunction. Her work also involves elucidating the molecular bases of inflammation and xenograft rejection in order to identify targets of intervention. Since early in her career, Dr. Costa developed an interest in cutting edge science and innovative therapies with emphasis on transplantation and transgenesis. She initiated her training with a veterinary medicine degree (Autonomous University of Barcelona, UAB) and conducted her PhD (1990-1995, UAB) obtaining some of the first transgenic animals in Spain under supervision of Dr. Fàtima Bosch. Her work during this period led to the generation of various transgenic mouse lines that are still in use for research in diabetes and retinopathy. During her PhD she also isolated and studied rodent pancreatic islets and later used this expertise for transplantation in mouse models. As a result of her PhD work she was involved in 6 funded projects and generated 5 highly-rated publications and one patent application. She continued to consolidate her career in science with a vision of using genetically-engineered parenchymal cells and tissues for therapeutic transplantation during her postdoctoral training and subsequent work at Alexion Pharmaceuticals (CT, USA) (1996-2004). Alexion pioneered this work by developing xenogeneic applications for cellular therapies based on genetic engineering of the source cell and animal (chondrocytes, ventral mesencephalon neural cells, Schwann cells and olfactory ensheathing cells). Dr. Costa played a major role in 4 of the funded projects at Alexion and produced 14 publications from this period (most as first author) and two patent applications. The xenotransplantation program was closed due to financial constrains in 2002 and Dr. Costa chose to continue this research line in Spain through the Ramon y Cajal program.
After her return to Spain she started a lab from scratch and led a small and international team that progresses much beyond the state of the art in the field of regenerative medicine and xenotransplantation. To this end, Dr. Costa has obtained from national sources and the European Commission 10 funded projects as principal investigator. Her research group has obtained good results and generated multiple congress communications, publications in international journals and book series (many as senior author), edited two books and participated in a highly-successful patent. In her training and teaching activities, she has directed numerous students at various levels including 7 masters (6 masters and 1 DEA) and 3 doctoral theses (by Mireia Uribe-Herranz, Roberta Sommaggio and Magdiel Pérez-Cruz). Her career as a biomedical scientist was officially acknowledged by the catalan agency AQU in 2011 (Acreditació de recerca) and continues associated with translational medicine and innovation. Dr. Costa has now developed high interests in education.
Research Interests
Papers共 311 篇Author StatisticsCo-AuthorSimilar Experts
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Guillaume Guimbretiere,Thomas Senage, Anne-Sophie Boureau, Jean-Charles Roos, Quentin Bernard, Baptiste Carlier, Joelle Veziers,Caroline Cueff,Nicolas Piriou, Guenola Coste,Imen Fellah, Coline Lelarge,
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGINGno. 3 (2024): 244-245
ENDOCRINOLOGIA DIABETES Y NUTRICIONno. 6 (2023): 421-428
Journal of advanced research (2023)
Bioengineering (Basel, Switzerland)no. 7 (2023): 833-833
BIOENGINEERING-BASELno. 7 (2023)
FRONTIERS IN IMMUNOLOGY (2023)
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