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个人简介
Biography
Dr. Wilen is an Assistant Professor in Laboratory Medicine and Immunobiology and is focused on the host-pathogen interactions of RNA viruses including coronavirus and norovirus. Dr. Wilen received his A.B in Biology and Economics at Washington University in St. Louis, his MD and PhD from the University of Pennsylvania. His residency training was in clinical pathology at Barnes-Jewish Hospital in St. Louis, MO. His postdoctoral studies were conducted in the laboratory of Herbert "Skip" Virgin at Washington University School of Medicine where he studied the pathogenesis of norovirus, the leading cause of acute gastroenteritis. Dr. Wilen discovered CD300lf as the first receptor for a norovirus and identified intestinal tuft cells as the physiologic target cell for mouse norovirus infection. Current work in the Wilen lab is focused on identifying novel therapeutic targets for SARS-CoV2 and elucidating mechanisms COVID-19 pathogenesis. The Wilen lab utilizes a diverse array of techniques to achieve these goals with SARS-CoV2 in the BSL3 including single-cell RNA sequencing, genome-wide CRISPR screening, organoid culture, and transgenic mouse models.
Dr. Wilen is an Assistant Professor in Laboratory Medicine and Immunobiology and is focused on the host-pathogen interactions of RNA viruses including coronavirus and norovirus. Dr. Wilen received his A.B in Biology and Economics at Washington University in St. Louis, his MD and PhD from the University of Pennsylvania. His residency training was in clinical pathology at Barnes-Jewish Hospital in St. Louis, MO. His postdoctoral studies were conducted in the laboratory of Herbert "Skip" Virgin at Washington University School of Medicine where he studied the pathogenesis of norovirus, the leading cause of acute gastroenteritis. Dr. Wilen discovered CD300lf as the first receptor for a norovirus and identified intestinal tuft cells as the physiologic target cell for mouse norovirus infection. Current work in the Wilen lab is focused on identifying novel therapeutic targets for SARS-CoV2 and elucidating mechanisms COVID-19 pathogenesis. The Wilen lab utilizes a diverse array of techniques to achieve these goals with SARS-CoV2 in the BSL3 including single-cell RNA sequencing, genome-wide CRISPR screening, organoid culture, and transgenic mouse models.
研究兴趣
论文共 126 篇作者统计合作学者相似作者
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Tianyang Mao,Jooyoung Kim,Mario A Peña-Hernández, Gabrielee Valle,Miyu Moriyama,Sophia Luyten,Isabel M Ott, Maria Luisa Gomez-Calvo,Jeff R Gehlhausen, Emily Baker,Benjamin Israelow,Martin Slade,
Madison S. Strine,Eric Fagerberg,Patrick W. Darcy,Gabriel M. Barron,Renata B. Filler,Mia Madel Alfajaro, Nicole D'Angelo-Gavrish, Fang Wang,Vincent R. Graziano,Bridget L. Menasche,Martina Damo,Ya-Ting Wang,
Rania Dagher, Aigul Moldobaeva,Elise Gubbins, Sydney Clark,Mia Madel Alfajaro,Craig B. Wilen,Finn Hawkins,Xiaotao Qu,Chia Chien Chiang, Yang Li,Lori Clarke, Yasuhiro Ikeda,
STEM CELLSno. 3 (2024): 230-250
Nature Communicationsno. 1 (2023): 1-11
PLoS pathogensno. 7 (2023)
GENOME BIOLOGY AND EVOLUTIONno. 4 (2023)
Cancer cellno. 8 (2023): 1516-1534.e9
Journal of Immunologyno. 1 (2023): 236.01-236.01
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