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职业迁徙
个人简介
My first area of interest is the identification and characterisation of both inherited and somatic genetic variants associated with cancer. We use statistical genetics and bioinformatics tools to fine-map cancer-associated genomic regions, and functional genomics to identify the candidate causal variants and their mechanism of action. We collaborate with colleagues in the School of Mathematics and Statistics in developing new statistical genomics approaches and in the mathematical modelling of the effects of inherited variants on cancer hallmark phenotypes.
My second area of interest is the use of circulating cell-free DNA as a source of tumour biomarkers. Tumours shed DNA into the circulation (ctDNA), and the ctDNA can be used to identify therapeutically-relevant tumour mutations and prognostic biomarkers. We are using low coverage highly parallel sequencing for copy number analysis, and digital droplet PCR and targeted sequencing for mutation analysis, to identify predictive and prognostic markers in a number of common cancers for which we have sample resources.
研究兴趣
论文共 343 篇作者统计合作学者相似作者
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medRxiv : the preprint server for health sciences (2024)
Cancer researchno. 4 (2024): 616-625
Katherine A Kentistou,Lena R Kaisinger,Stasa Stankovic,Marc Vaudel, Edson Mendes de Oliveira,Andrea Messina,Robin G Walters,Xiaoxi Liu,Alexander S Busch,Hannes Helgason,Deborah J Thompson, Federico Santoni,
Katherine A Kentistou,Lena R Kaisinger,Stasa Stankovic,Marc Vaudel,Edson Mendes de Oliveira,Andrea Messina,Robin G Walters,Xiaoxi Liu, Alexander S Busch,Hannes Helgason,Deborah J Thompson, Federico Santoni,
Nature genetics (2024)
Yafang Li,Xiangjun Xiao,Jianrong Li,Younghun Han, Chao Cheng,Gail F Fernandes, Shannon E Slewitzke,Susan M Rosenberg,Meng Zhu,Jinyoung Byun,Yohan Bossé,James D McKay,
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncologyno. 3 (2024): 389-399
crossref(2023)
The Lancet. Public healthno. 9 (2023): e691-e700
Nicola J. Camp,Wei-Yu Lin,Alex Bigelow,George J. Burghel,Timothy L. Mosbruger, Marina A. Parry,Rosalie G. Waller,Sushilaben H. Rigas, Pei-Yi Tai,Kristofer Berrett,Venkatesh Rajamanickam, Rachel Cosby,
crossref(2023)
Journal of Medical Geneticsno. 12 (2023): 1186-1197
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